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Sucnr1 - succinate receptor 1 Gene

Also Known as Gpr91

Species: Mus musculus

Gene Type: protein coding

Gene ID: 84112

About Sucnr1

Chromosome 3: 59,989,290-59,994,987 forward strand.GRCm39:CM000996.3

This gene has 2 transcripts (splice variants), 211 orthologues, 13 paralogues and is associated with 8 phenotypes. Biased expression in subcutaneous fat pad adult (RPKM 18.1), genital fat pad adult (RPKM 15.8) and 3 other tissues.

Summary

Enables signaling receptor activity. Acts upstream of or within several processes, including macrophage activation involved in immune response; regulation of angiotensin metabolic process; and Renin secretion into blood stream. Predicted to be located in cell surface. Is expressed in neural retina and retina. Orthologous to human SUCNR1 (Succinate Receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Sucnr1 Products (2)

mRNA	Protein	Name
NM_032400.2	NP_115776.2	succinate receptor 1
NM_032400.2	NP_115776.2	succinate receptor 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables G protein-coupled receptor activity	IDA IDA: Inferred from direct assay	18820681	MGI
enables signaling receptor activity	IDA IDA: Inferred from direct assay	27481132	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	18820681	MGI
involved in energy homeostasis	IDA IDA: Inferred from direct assay	36977414	MGI
acts upstream of or within glucose homeostasis	IMP IMP: Inferred from mutant phenotype	28382382	MGI
acts upstream of or within interleukin-1 beta production	IMP IMP: Inferred from mutant phenotype	27481132	MGI
acts upstream of or within macrophage activation involved in immune response	IMP IMP: Inferred from mutant phenotype	27481132	MGI
acts upstream of or within macrophage cytokine production	IMP IMP: Inferred from mutant phenotype	27481132	MGI
acts upstream of or within positive regulation of chemotaxis	IMP IMP: Inferred from mutant phenotype	28382382	MGI
acts upstream of or within positive regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	28382382	MGI
acts upstream of or within regulation of angiotensin metabolic process	IMP IMP: Inferred from mutant phenotype	18535668	MGI
acts upstream of or within renin secretion into blood stream	IMP IMP: Inferred from mutant phenotype	18535668	MGI
acts upstream of or within response to calcium ion	IMP IMP: Inferred from mutant phenotype	18535668	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Sucnr1 Protein Structure

7tm_GPCRs

0
100
200
300
317 a.a.

Protein Preferred Names	Protein Names
succinate receptor 1	G protein-coupled receptor 91

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-130246	NF-56-EJ40		99.88%	Unkown
HY-125791	cis-Epoxysuccinic acid	Agonist	98.0%	Unkown
HY-150205	Succinate/succinate receptor antagonist 1	Antagonist	99.40%	Unkown
HY-154946	SUCNR1-IN-1	Inhibitor	99.39%	Unkown
HY-156955	SUCNR1-IN-2	Inhibitor	99.74%	Unkown
HY-RS14004	Sucnr1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-130246A	NF-56-EJ40 hydrochloride		98.45%	Unkown
HY-N1910	4'-O-Methylbavachalcone	Inhibitor	99.64%	Unkown
HY-RS14003	SUCNR1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-183639	SUCNR1 antagonist-1		/	Unkown
HY-RS14005	Sucnr1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sucnr1	NCBI	NCBI:56670