SUCNR1 - succinate receptor 1 Gene

Also Known as GPR91

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 56670

About SUCNR1

Cytogenetic location: 3q25.1 Genomic coordinates (GRCh38): 3:151,873,643-151,884,619 (from NCBI)

This gene has 1 transcript (splice variant), 211 orthologues and 15 paralogues. Biased expression in kidney (RPKM 20.6), thyroid (RPKM 7.3) and 7 other tissues.

Summary

This gene encodes a G-protein-coupled receptor for succinate, an intermediate molecule of the citric acid cycle. It is involved in the promotion of hematopoietic progenitor cell development, and it has a potential role in renovascular hypertension which has known correlations to renal failure, diabetes and atherosclerosis. [provided by RefSeq, Oct 2009]

SUCNR1 Products (1)

mRNA Protein Name
NM_033050.6 NP_149039.2 succinate receptor 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled receptor activity IDA
IDA: Inferred from direct assay
18820681 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
18820681 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
15141213 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SUCNR1 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (40 - 295)

  • 0
  • 100
  • 200
  • 300
  • 334 a.a.
Protein Preferred Names Protein Names

succinate receptor 1

  • G-protein coupled receptor 91

  • P2Y purinoceptor 1

SUCNR1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SUCNR1 Q9BXA5 LAMP2 Homo sapiens P13473-2
Y2H Pooling
32814053
Intra
SUCNR1 Q9BXA5 LAMP2 Homo sapiens P13473-2
Validated Y2H
32814053
Intra
SUCNR1 Q9BXA5 LAMP2 Homo sapiens P13473-2
Y2H Array
32814053
Intra
SUCNR1 Q9BXA5 SH3GLB1 Homo sapiens Q9Y371
Validated Y2H
32814053
Intra
SUCNR1 Q9BXA5 SH3GLB1 Homo sapiens Q9Y371
Y2H Array
32814053
Intra
SUCNR1 Q9BXA5 SH3GLB1 Homo sapiens Q9Y371
Y2H Pooling
32814053
Intra
SUCNR1 Q9BXA5 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Intra
SUCNR1 Q9BXA5 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Intra
SUCNR1 Q9BXA5 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Exudative Vitreoretinopathy 1

  • Retinopathy Of Prematurity

  • Retrolental Fibroplasia

  • EVR1

  • Criswick-Schepens Syndrome

  • Rop

  • Exudative Vitreoretinopathy, Familial, Autosomal Dominant

  • Fevr, Autosomal Dominant

  • Premature Retinopathy

  • Vitreoretinopathy, Exudative 1

  • Autosomal Dominant Familial Exudative Vitreoretinopathy

  • Fevr

  • Vitreoretinopathy, Exudative, Type 1

  • Retinopathy Of Prematurity Nos

  • Rlf- [Retrolental Fibroplasia]

  • Rop - [Retinopathy Of Prematurity]

  • Terry Syndrome
Renovascular Hypertension

  • Hypertension, Renovascular

  • Hypertension Renovascular
Mooren'S Ulcer

  • Mooren Ulcer

  • Moorens Ulcer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-130246 NF-56-EJ40 99.88% Unkown
HY-125791 cis-Epoxysuccinic acid Agonist 98.0% Unkown
HY-150205 Succinate/succinate receptor antagonist 1 Antagonist 99.40% Unkown
HY-154946 SUCNR1-IN-1 Inhibitor 99.39% Unkown
HY-156955 SUCNR1-IN-2 Inhibitor 99.74% Unkown
HY-RS14004 Sucnr1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-130246A NF-56-EJ40 hydrochloride 98.45% Unkown
HY-N1910 4'-O-Methylbavachalcone Inhibitor 99.64% Unkown
HY-RS14003 SUCNR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-183639 SUCNR1 antagonist-1 / Unkown
HY-RS14005 Sucnr1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SUCNR1 MGD MGI:1934135
Canis familiaris SUCNR1 VGNC VGNC:46968
Macaca mulatta SUCNR1 VGNC VGNC:110337
Rattus norvegicus SUCNR1 RGD RGD:1303193
Felis catus SUCNR1 VGNC VGNC:67448
Bos taurus SUCNR1 VGNC VGNC:35458
Others SUCNR1 NCBI