2. Gene
  3. Kars - lysyl-tRNA synthetase Gene

Kars - lysyl-tRNA synthetase Gene

  • Gene
  • Protein
  • Agent
Mus musculus

Also known as Kars1; LysRS; D8Wsu108e; mKIAA0070; D8Ertd698e

Gene ID: 85305 | Gene type: protein coding

About Kars

Summary

Enables scaffold protein binding activity. Predicted to be involved in several processes, including ERK1 and ERK2 cascade; diadenosine tetraphosphate biosynthetic process; and lysyl-tRNA aminoacylation. Predicted to act upstream of or within translation. Located in mitochondrion. Part of Aminoacyl-tRNA Synthetase multienzyme complex. Is expressed in several structures, including alimentary system; central nervous system; cranium; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease recessive intermediate B and autosomal recessive nonsyndromic deafness 89. Orthologous to human KARS1 (lysyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]

Kars Products(5)

mRNA Protein Name
NM_001130868.2 NP_001124340.1 lysine--tRNA ligase isoform 1
NM_001286384.1 NP_001273313.1 lysine--tRNA ligase isoform 1
NM_001363429.1 NP_001350358.1 lysine--tRNA ligase isoform 1
NM_001363430.1 NP_001350359.1 lysine--tRNA ligase isoform 1
NM_053092.3 NP_444322.1 lysine--tRNA ligase isoform 2
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables scaffold protein binding IPI
IPI: Inferred from physical interaction
12060739 MGI
Cellular Component GO Annotation Evidence Reference Source
part of aminoacyl-tRNA synthetase multienzyme complex IDA
IDA: Inferred from direct assay
12060739 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lysine--tRNA ligase

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-101124 Rodatristat ethyl Inhibitor 99.82% Phase 2
Pre-clinical Phase
Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-W451275 HG106 Activator 99.90% Unkown
HY-129086 BPAM344 Agonist 99.66% Unkown
HY-120083 Rodatristat Inhibitor 98.41% Unkown
HY-168432 KK181N1 99.83% Unkown
HY-117759 Deacetoxyvinzolidine Inhibitor / Unkown
HY-119781 Kaitocephalin Antagonist / Unkown
HY-180562 KARS-IN-1 Inhibitor / Unkown
HY-RS07071 KARS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-116552 KAR425 Inhibitor / Unkown
HY-N2369B (-)-Chelidonine / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P991156 Rapaprutug Ligand / Unkown