Ciita - class II, major histocompatibility complex, transactivator Gene

Also Known as C2ta; Mhc2ta

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 85483

Summary

Predicted to enable DNA-binding transcription factor binding activity; protein C-terminus binding activity; and transcription cis-regulatory region binding activity. Involved in several processes, including cellular response to electrical stimulus; cellular response to exogenous dsRNA; and regulation of macromolecule biosynthetic process. Located in cell surface. Used to study periapical periodontitis. Human ortholog(s) of this gene implicated in Addison's disease; MHC class II deficiency; autoimmune disease (multiple); and myocardial infarction. Orthologous to human CIITA (class II major histocompatibility complex transactivator). [provided by Alliance of Genome Resources, Apr 2022]

Ciita Products (3)

mRNA Protein Name
NM_001270803.1 NP_001257732.1 MHC class II transactivator isoform 2
NM_001270804.1 NP_001257733.1 MHC class II transactivator isoform 3
NM_053529.2 NP_445981.2 MHC class II transactivator isoform 1

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in cellular response to electrical stimulus IEP
IEP: Inferred from expression pattern
10051633 RGD
involved in cellular response to exogenous dsRNA IEP
IEP: Inferred from expression pattern
10051633 RGD
involved in cellular response to type II interferon IEP
IEP: Inferred from expression pattern
11071855 RGD
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
11071855 RGD
involved in positive regulation of MHC class II biosynthetic process IDA
IDA: Inferred from direct assay
11071855 RGD
involved in positive regulation of MHC class II biosynthetic process IEP
IEP: Inferred from expression pattern
11477547 RGD
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
11071855 RGD
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
23524893 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

MHC class II transactivator

  • MHC class II transactivator type IV

  • class II transactivator

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02714 CIITA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19181 Ciita Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25669 Ciita Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ciita NCBI NCBI:4261