CDC14B - cell division cycle 14B Gene

Also Known as CDC14B3; Cdc14B1; Cdc14B2; hCDC14B

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8555

About CDC14B

Cytogenetic location: 9q22.32-q22.33 Genomic coordinates (GRCh38): 9:96,490,939-96,619,843 (from NCBI)

This gene has 13 transcripts (splice variants), 130 orthologues and 8 paralogues. Ubiquitous expression in thyroid (RPKM 7.4), testis (RPKM 5.3) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the dual specificity protein tyrosine Phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine Phosphatase involved in the exit of cell Mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

CDC14B Products (7)

mRNA	Protein	Name
NM_001077181.3	NP_001070649.1	dual specificity protein phosphatase CDC14B isoform 3
NM_001351567.3	NP_001338496.1	dual specificity protein phosphatase CDC14B isoform 4
NM_001351568.3	NP_001338497.1	dual specificity protein phosphatase CDC14B isoform 5
NM_001351569.2	NP_001338498.1	dual specificity protein phosphatase CDC14B isoform 5
NM_001351570.1	NP_001338499.1	dual specificity protein phosphatase CDC14B isoform 6
NM_003671.5	NP_003662.1	dual specificity protein phosphatase CDC14B isoform 1
NM_033331.4	NP_201588.1	dual specificity protein phosphatase CDC14B isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12697818	GOA
enables protein serine/threonine phosphatase activity	IDA IDA: Inferred from direct assay	9367992	GOA
enables protein tyrosine phosphatase activity	IDA IDA: Inferred from direct assay	9367992	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in mitotic G2 DNA damage checkpoint signaling	IDA IDA: Inferred from direct assay	18662541	GOA
involved in positive regulation of ubiquitin protein ligase activity	IMP IMP: Inferred from mutant phenotype	18662541	GOA
involved in protein dephosphorylation	IMP IMP: Inferred from mutant phenotype	18662541	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleolus	IDA IDA: Inferred from direct assay	18662541	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	18662541	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9367992	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDC14B Protein Structure

DSPn

DSPc

0
100
200
300
400
498 a.a.

Protein Preferred Names	Protein Names
dual specificity protein phosphatase CDC14B	CDC14 cell division cycle 14 homolog B

CDC14B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CDC14B	O60729	MFAP1	Homo sapiens	P55081	Validated Y2H	32296183
Intra	CDC14B	O60729	ZNF696	Homo sapiens	Q9H7X3	Validated Y2H	32296183
Intra	CDC14B	O60729	SPANXN2	Homo sapiens	Q5MJ10	Validated Y2H	32296183
Intra	CDC14B	O60729	PSMB1	Homo sapiens	P20618	Validated Y2H	32296183
Intra	CDC14B	O60729	SIRT2	Homo sapiens	Q8IXJ6	Anti Bait CoIP	12697818
Intra	CDC14B	O60729	SIRT2	Homo sapiens	Q8IXJ6	Pull Down	12697818

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Adrenal Gland Pheochromocytoma	Pheochromocytoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-161673	CDC14A/B-IN-1	Inhibitor	/	Unkown
HY-206735	CDC14A/B-IN-2	Inhibitor	/	Unkown
HY-RS02286	CDC14B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16132	ZNF367 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CDC14B	VGNC	VGNC:56939
Mus musculus	CDC14B	MGD	MGI:2441808
Macaca mulatta	CDC14B	VGNC	VGNC:103247
Rattus norvegicus	CDC14B	RGD	RGD:1311163
Canis familiaris	CDC14B	VGNC	VGNC:53688
Others	CDC14B	NCBI