BPIFB1 - BPI fold containing family B member 1 Gene

Also Known as LPLUNC1; C20orf114

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 92747

About BPIFB1

This gene has 3 transcripts (splice variants), 93 orthologues and 12 paralogues. Biased expression in stomach (RPKM 277.8), lung (RPKM 49.9) and 2 other tissues.

Summary

The protein encoded by this gene may be involved in the innate immune response to Bacterial exposure in the mouth, nasal cavities, and lungs. The encoded protein is secreted and is a member of the BPI/LBP/PLUNC protein superfamily. This gene is found with Other members of the superfamily in a cluster on chromosome 20. [provided by RefSeq, Jul 2008]

BPIFB1 Products (1)

mRNA	Protein	Name
NM_033197.3	NP_149974.2	BPI fold-containing family B member 1 precursor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	References	Source
involved in innate immune response in mucosa	IDA IDA: Inferred from direct assay	21900486	GOA
involved in negative regulation of toll-like receptor 4 signaling pathway	IDA IDA: Inferred from direct assay	21900486	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular region	IDA IDA: Inferred from direct assay	20237794	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BPIFB1 Protein Structure

LBP_BPI_CETP

LBP_BPI_CETP_C

0
100
200
300
400
484 a.a.

Protein Preferred Names	Protein Names
BPI fold-containing family B member 1	VEMSGP

Recombinant BPIFB1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76178	BPIFB1 Protein, Human (HEK293, His)	Q8TDL5 (T22-Q484)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Cholera	Vibrio Cholerae Infection Cholera - Vibrio Cholerae Cholera Due To Vibrio Cholerae Vibrio Cholerae Cholera Syndrome Asiatic Cholera Epidemic Cholera
Papillary Cystadenocarcinoma	Cystadenocarcinoma, Papillary
Autoimmune Polyendocrine Syndrome Type 1	Whitaker Syndrome Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Autoimmune Polyglandular Syndrome I Polyglandular Type I Autoimmune Syndrome
Chronic Mucocutaneous Candidiasis	Candidiasis, Chronic Mucocutaneous Cmc Candidiasis Chronic Mucocutaneous
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01583	BPIFB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18852	Bpifb1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25344	Bpifb1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	BPIFB1	VGNC	VGNC:26545
Felis catus	BPIFB1	VGNC	VGNC:60155
Macaca mulatta	BPIFB1	VGNC	VGNC:107774
Canis familiaris	BPIFB1	VGNC	VGNC:38507
Mus musculus	BPIFB1	MGD	MGI:2137431
Rattus norvegicus	BPIFB1	RGD	RGD:1563047
Others	BPIFB1	NCBI