BPIFB1 Protein, Human (HEK293, His)

The BPIFB1 protein may play a crucial role in innate immunity, particularly in the mouth, nose, and lungs, against microbial threats. It binds to bacterial lipopolysaccharide (LPS), modulates cellular responses and affects LPS-triggered immune signaling pathways. BPIFB1 Protein, Human (HEK293, His) is the recombinant human-derived BPIFB1 protein, expressed by HEK293 , with C-His labeled tag.

The BPIFB1 protein is suggested to potentially play a crucial role in innate immunity, particularly in the regions of the mouth, nose, and lungs, highlighting its significance in the defense against microbial threats at mucosal surfaces. Functionally, BPIFB1 is known to bind bacterial lipopolysaccharide (LPS), a key component of bacterial cell walls, and it modulates cellular responses to LPS. This interaction implies a role for BPIFB1 in regulating immune responses to bacterial infections by influencing the cellular signaling pathways triggered by LPS. The specific mechanisms by which BPIFB1 contributes to innate immunity and its precise role in mucosal defense remain areas of interest, underscoring the need for further investigation to elucidate its functions and molecular interactions in the context of immune defense in the upper respiratory and oral regions.

Human

HEK293

C-His

Q8TDL5 (T22-Q484)

92747  [NCBI]

Full Length of Mature Protein

TLSPTAVLILGPKVIKEKLTQELKDHNATSILQQLPLLSAMREKPAGGIPVLGSLVNTVLKHIIWLKVITANILQLQVKPSANDQELLVKIPLDMVAGFNTPLVKTIVEFHMTTEAQATIRMDTSASGPTRLVLSDCATSHGSLRIQLLHKLSFLVNALAKQVMNLLVPSLPNLVKNQLCPVIEASFNGMYADLLQLVKVPISLSIDRLEFDLLYPAIKGDTIQLYLGAKLLDSQGKVTKWFNNSAASLTMPTLDNIPFSLIVSQDVVKAAVAAVLSPEEFMVLLDSVLPESAHRLKSSIGLINEKAADKLGSTQIVKILTQDTPEFFIDQGHAKVAQLIVLEVFPSSEALRPLFTLGIEASSEAQFYTKGDQLILNLNNISSDRIQLMNSGIGWFQPDVLKNIITEIIHSILLPNQNGKLRSGVPVSLVKALGFEAAESSLTKDALVLTPASLWKPSSPVSQ

Approximately 53 kDa,based on SDS-PAGE under reducing conditions.

≥ 95%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.