BPIFB1 Protein, Human (HEK293, His)
Based on 1 Customer Validation
The BPIFB1 protein may play a crucial role in innate immunity, particularly in the mouth, nose, and lungs, against microbial threats. It binds to bacterial lipopolysaccharide (LPS), modulates cellular responses and affects LPS-triggered immune signaling pathways. BPIFB1 Protein, Human (HEK293, His) is the recombinant human-derived BPIFB1 protein, expressed by HEK293 , with C-His labeled tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
The BPIFB1 protein may play a crucial role in innate immunity, particularly in the mouth, nose, and lungs, against microbial threats. It binds to bacterial lipopolysaccharide (LPS), modulates cellular responses and affects LPS-triggered immune signaling pathways. BPIFB1 Protein, Human (HEK293, His) is the recombinant human-derived BPIFB1 protein, expressed by HEK293 , with C-His labeled tag.
Background
The BPIFB1 protein is suggested to potentially play a crucial role in innate immunity, particularly in the regions of the mouth, nose, and lungs, highlighting its significance in the defense against microbial threats at mucosal surfaces. Functionally, BPIFB1 is known to bind bacterial lipopolysaccharide (LPS), a key component of bacterial cell walls, and it modulates cellular responses to LPS. This interaction implies a role for BPIFB1 in regulating immune responses to bacterial infections by influencing the cellular signaling pathways triggered by LPS. The specific mechanisms by which BPIFB1 contributes to innate immunity and its precise role in mucosal defense remain areas of interest, underscoring the need for further investigation to elucidate its functions and molecular interactions in the context of immune defense in the upper respiratory and oral regions.
Technical Parameters
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Species Human
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Source HEK293
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Tag C-His
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Accession
Q8TDL5 (T22-Q484)
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Molecular Construction
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N-term
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BPIFB1 (T22-Q484)
Accession # Q8TDL5 -
His
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C-term
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Protein Length
Full Length of Mature Protein
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Synonyms
BPIFB1; BPI Fold-Containing Family B Member 1; Prev. C20orf114; BA49G10.6; LPLUNC1; MGC14597; VEMSGP; Long Palate, Lung And Nasal Epithelium Carcinoma Associated 1; Von Ebner Minor Salivary Gland Protein; Chromosome 20 Open Reading Frame 114; Long Palate,
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AA Sequence
TLSPTAVLILGPKVIKEKLTQELKDHNATSILQQLPLLSAMREKPAGGIPVLGSLVNTVLKHIIWLKVITANILQLQVKPSANDQELLVKIPLDMVAGFNTPLVKTIVEFHMTTEAQATIRMDTSASGPTRLVLSDCATSHGSLRIQLLHKLSFLVNALAKQVMNLLVPSLPNLVKNQLCPVIEASFNGMYADLLQLVKVPISLSIDRLEFDLLYPAIKGDTIQLYLGAKLLDSQGKVTKWFNNSAASLTMPTLDNIPFSLIVSQDVVKAAVAAVLSPEEFMVLLDSVLPESAHRLKSSIGLINEKAADKLGSTQIVKILTQDTPEFFIDQGHAKVAQLIVLEVFPSSEALRPLFTLGIEASSEAQFYTKGDQLILNLNNISSDRIQLMNSGIGWFQPDVLKNIITEIIHSILLPNQNGKLRSGVPVSLVKALGFEAAESSLTKDALVLTPASLWKPSSPVSQ
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Predicted Molecular Mass
51.7 kDa
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Molecular Weight
Approximately 53 kDa, based on SDS-PAGE under reducing conditions.
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Glycosylation
Yes
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
Lyophilized from a 0.2 μm filtered solution of 20 mM HEPES, 150 mM NaCl, 8% glycerol, 10% trehalose, 0.02% Tween 80, pH 7.5.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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