Nucks1 - nuclear casein kinase and cyclin-dependent kinase substrate 1 Gene

Also Known as Nucks; 2700010L10Rik; 8430423A01Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 98415

Summary

Predicted to enable DNA binding activity; chromatin binding activity; and transcription coactivator activity. Involved in several processes, including cellular glucose homeostasis; positive regulation of transcription by RNA polymerase II; and regulation of Insulin Receptor signaling pathway. Acts upstream of or within glucose homeostasis and positive regulation of Insulin Receptor signaling pathway. Located in chromatin; cytoplasm; and nucleus. Is expressed in central nervous system; embryo; liver; retina inner nuclear layer; and retina outer nuclear layer. Orthologous to human NUCKS1 (nuclear Casein Kinase and cyclin dependent kinase substrate 1). [provided by Alliance of Genome Resources, Apr 2022]

Nucks1 Products (2)

mRNA	Protein	Name
NM_001145804.1	NP_001139276.1	nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 isoform 2
NM_175294.3	NP_780503.2	nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 isoform 1

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	References	Source
involved in chromatin organization	IMP IMP: Inferred from mutant phenotype	24931609	MGI
acts upstream of or within glucose homeostasis	IMP IMP: Inferred from mutant phenotype	24931609	MGI
involved in intracellular glucose homeostasis	IMP IMP: Inferred from mutant phenotype	26205492	MGI
acts upstream of or within positive regulation of insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	24931609	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	24931609	MGI
involved in regulation of insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	26205492	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in chromatin	IDA IDA: Inferred from direct assay	26205492	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	3000779	MGI
located in nucleus	IDA IDA: Inferred from direct assay	3000779	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
nuclear ubiquitous casein and cyclin-dependent kinase substrate 1	JC7 nuclear ubiquitous casein and cyclin-dependent kinases substrate nuclear, casein kinase and cyclin-dependent kinase substrate

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09656	NUCKS1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nucks1	NCBI	NCBI:64710