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Cat. No.: HY-P10081

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CTP-NBD

CTP-NBD is a cell permeable specific NFκB peptide inhibitor. CTP-NBD could be used in colitis study

For research use only. We do not sell to patients.

CAS No.: 1268513-27-4
Formula: C₁₂₁H₁₉₄N₄₆O₃₂
Molecular Weight:2805.12

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CTP-NBD Chemical Structure

CAS No.: 1268513-27-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

CTP-NBD is a cell permeable specific NFκB peptide inhibitor. CTP-NBD could be used in colitis study^[1]^[2]

All NF-κB Isoforms :

In Vitro

CTP-NBD (200 μM, 6 h) inhibits TNF-α induced luciferase activity in HCT116 cells^[1].
CTP-NBD (200 μM, 6 h) inhibits the expression of IL-8, INOS and COX-2 in RAW264.7 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Immunofluorescence^[1]

Cell Line:

HCT116
Concentration:

200 μM
Incubation Time:

6 h
Result:

Inhibited the luciferase activity induced by TNF-α.

Western Blot Analysis^[1]

Cell Line:

RAW264.7
Concentration:

200 μM
Incubation Time:

6 h
Result:

Inhibited the express of INOS and COX-2 protein.

In Vivo

CTP-NBD can not effectively reduce inflammation in colitis rat model, but the modified Colon-targeted CTP-NBD has oral activity and can reduce inflammation in colitis rat model ^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1268513-27-4
Molecular Weight 2805.12
Formula C₁₂₁H₁₉₄N₄₆O₃₂
Sequence

Tyr-Gly-Arg-Arg-Ala-Arg-Arg-Arg-Ala-Arg-Arg-Thr-Ala-Leu-Asp-Trp-Ser-Trp-Leu-Gln-Thr-Glu
Sequence Shortening

YGRRARRRARRTALDWSWLQTE
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (261 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lee Y, et al. Colon-targeted celecoxib ameliorates TNBS-induced rat colitis: a potential pharmacologic mechanism and therapeutic advantages. Eur J Pharmacol. 2014 Mar 5;726:49-56 [Content Brief]

[2]. Hong S, et al. Colon-targeted cell-permeable NFκB inhibitory peptide is orally active against experimental colitis. Mol Pharm. 2012 May 7;9(5):1310-9. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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CTP-NBD

All NF-κB Isoforms