SLC7A11 - solute carrier family 7 member 11 Gene

Also Known as xCT; CCBR1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23657

About SLC7A11

Cytogenetic location: 4q28.3 Genomic coordinates (GRCh38): 4:138,164,097-138,312,671 (from NCBI)

This gene has 2 transcripts (splice variants), 289 orthologues and 12 paralogues. Biased expression in brain (RPKM 12.7), thyroid (RPKM 4.9) and 8 other tissues.

Summary

This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. [provided by RefSeq, Sep 2011]

SLC7A11 Products (1)

mRNA	Protein	Name
NM_014331.4	NP_055146.1	cystine/glutamate transporter

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables L-kynurenine transmembrane transporter activity	IDA IDA: Inferred from direct assay	35245456	GOA
enables cystine:glutamate antiporter activity	IDA IDA: Inferred from direct assay	11417227	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21397861	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in L-cystine transport	IDA IDA: Inferred from direct assay	11133847	GOA
involved in L-glutamate transmembrane transport	IDA IDA: Inferred from direct assay	11133847	GOA
involved in L-kynurenine transmembrane transport	IDA IDA: Inferred from direct assay	35245456	GOA
involved in negative regulation of ferroptosis	IDA IDA: Inferred from direct assay	35245456	GOA
involved in response to toxic substance	IDA IDA: Inferred from direct assay	17575980	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	25063885	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	11417227	GOA
located in plasma membrane	IPI IPI: Inferred from physical interaction	34880232	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC7A11 Protein Structure

AA_permease_2

0
100
200
300
400
501 a.a.

Protein Preferred Names	Protein Names
cystine/glutamate transporter	amino acid transport system xc-

SLC7A11 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SLC7A11	Q9UPY5	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Array	32296183
Intra	SLC7A11	Q9UPY5	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Prey Pooling	32296183
Intra	SLC7A11	Q9UPY5	KRTAP1-1	Homo sapiens	Q07627	Y2H Array	32296183
Intra	SLC7A11	Q9UPY5	KRTAP1-1	Homo sapiens	Q07627	Y2H Prey Pooling	32296183
Intra	SLC7A11	Q9UPY5	CD44	Homo sapiens	P16070	Anti Bait CoIP	21397861

Cross: Cross-species interaction Intra: Intraspecies interaction

SLC7A11 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80523	xCT Antibody (YA652)	WB, IHC-P, ICC/IF, FC	Human, Mouse
HY-P80935	xCT Antibody (YA006)	WB, IP	Human, Mouse
HY-P86499	xCT Antibody (YA6191)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Lysinuric Protein Intolerance	LPI Dibasic Amino Aciduria Ii Hyperdibasic Aminoaciduria Dibasic Aminoaciduria 2 Dibasicamino Aciduria Ii Congenital Lysinuria Lpi - Lysinuric Protein Intolerance
Cystinuria	CSNU Cystinuria Type B Cystinuria Type A Cystinuria, Type I, Formerly Csnu1, Formerly Cystinuria, Type Ii, Formerly Cystinuria, Type Iii, Formerly Csnu3, Formerly Cystinuria, Type Non-I, Formerly Cystinuria-Lysinuria Cystinuria-Lysinuria Syndrome Csnu1 Csnu3 Cystinuria 1 Cystinuria Type A/B Cystinuria Type I Cystinuria Type Ii Cystinuria Type Iii Cystinuria Type Non-I Cystinuria, Type A/B Cystinuria Type 1 Cystinuria - Lysinuria Csnu - [Cystinuria] Cystine Disease
Kaposi Sarcoma	Kaposi'S Sarcoma Kaposi Sarcoma, Susceptibility To Kaposi'S Sarcoma Of Lung Kaposi'S Sarcoma Of Palate Kaposi'S Sarcoma Of Soft Tissue Kaposi'S Sarcoma-Associated Herpesvirus Multiple Idiopathic Pigmented Hemangiosarcoma Multiple Idiopathic Pigmented Hemangiosarcoma, Susceptibility To African Lymphadenopathic Kaposi'S Sarcoma Anal Kaposi'S Sarcoma Cardiac Kaposi'S Sarcoma Central Nervous System Kaposi'S Sarcoma Conjunctival Kaposi'S Sarcoma Corneal Kaposi'S Sarcoma Cutaneous Kaposi'S Sarcoma Esophageal Kaposi'S Sarcoma Gallbladder Kaposi'S Sarcoma Gastric Kaposi'S Sarcoma Intestinal Kaposi'S Sarcoma Kaposi'S Sarcoma Of Anus Kaposi'S Sarcoma Of Central Nervous System Kaposi'S Sarcoma Of Conjunctiva Kaposi'S Sarcoma Of Cornea Kaposi'S Sarcoma Of Esophagus Kaposi'S Sarcoma Of Gastrointestinal Sites Kaposi'S Sarcoma Of Heart Kaposi'S Sarcoma Of Lymph Nodes Kaposi'S Sarcoma Of Penis Kaposi'S Sarcoma Of Skin Kaposi'S Sarcoma Of Soft Tissues Kaposi'S Sarcoma Of The Cns Kaposi'S Sarcoma Of The Gallbladder Kaposi'S Sarcoma Of The Prostate Kaposi'S Sarcoma, Lung Kaposi'S Sarcoma, Skin Lymph Node Kaposi'S Sarcoma Lymphadenopathic Kaposi'S Sarcoma Palate Kaposi'S Sarcoma Penis Kaposi'S Sarcoma Prostate Kaposi'S Sarcoma Pulmonary Kaposi'S Sarcoma Soft Tissue Kaposi'S Sarcoma Hhv8 Human Herpesvirus 8 Kshv Kaposi Sarcoma Herpesvirus Mediterranean Kaposi Sarcoma Non Aids Related Kaposi Sarcoma Sarcoma, Kaposi Sarcoma, Kaposi, Susceptibility To Non-Aids-Related Kaposi Sarcoma Angiolymphoid Hyperplasia Angiofollicular Ganglionic Hyperplasia Multi-Centric Castleman'S Disease
Occlusion Of Gallbladder	Obstruction Of Gallbladder Gallbladder Obstruction
Sarcoma	Connective And Soft Tissue Neoplasm Tumor Of Soft Tissue And Skeleton Sarcomas Sarcoma - Category
Brain Edema	Cerebral Edema Intracranial Swelling Wet Brain
Thyrotoxic Exophthalmos
Endocrine Exophthalmos	Endocrine Exopthalmos Thyroid Associated Opthalmopathies
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Developmental And Epileptic Encephalopathy 75	DEE75 Epileptic Encephalopathy, Early Infantile, 75 Eiee75 Developmental And Epileptic Encephalopathy, 75 Early Infantile Epileptic Encephalopathy 75

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0653A	Levobupivacaine hydrochloride		99.86%	Yes
HY-B0653	Levobupivacaine		99.66%	Yes

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-108894	Ferumoxytol	Inducer	95.00%	Phase 4
HY-W402682	SXC2023	Activator	99.85%	Phase 2

Pre-clinical Phase

Bioactive Molecules (31)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15763	Erastin		99.91%	Unkown
HY-W451275	HG106	Activator	99.90%	Unkown
HY-W018161	Hexadecanedioic acid	Inhibitor	98.0%	Unkown
HY-175032	ATF3-IN-1		96.30%	Unkown
HY-169056	SLC7A11-IN-2		99.80%	Unkown
HY-149979	SLC7A11-IN-1	Inducer	97.06%	Unkown
HY-RS13325	SLC7A11 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-N10549	Gigantol		99.79%	Unkown
HY-179041	SZ0232		99.25%	Unkown
HY-179528	DIM-3,5-Cl2		99.18%	Unkown
HY-183622	UCI-1014	Activator	98.43%	Unkown
HY-112005G	DOPE (GMP)	Inhibitor	/	Unkown
HY-155851	Lepadin E		/	Unkown
HY-155852	Lepadin H		/	Unkown
HY-161075	Microtubule inhibitor 8		/	Unkown
HY-176719	AKR1B1/STAT3/SLC7A11-regulator-1		/	Unkown
HY-180199	GPX4-IN-21		/	Unkown
HY-181982	HJ03		/	Unkown
HY-182052	Ferroptosis inducer-16		/	Unkown
HY-183554	Fa-Au		/	Unkown
HY-184115	JHB-17		/	Unkown
HY-184266	GCLCi0	Inducer	/	Unkown
HY-184267	GCLCi1		/	Unkown
HY-184761	Keap1-Nrf2-IN-30		/	Unkown
HY-B0653AS	Levobupivacaine-d9 hydrochloride		/	Unkown
HY-D3311	M1219		/	Unkown
HY-N17850	5-Hydroxy-6,7-dimethoxyflavone		/	Unkown
HY-P5762A	Phoenixin-14 TFA		/	Unkown
HY-W018161S	Hexadecanedioic acid-d28		99.21%	Unkown
HY-RS16551	Slc7a11 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22984	Slc7a11 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SLC7A11	MGD	MGI:1347355
Canis familiaris	SLC7A11	VGNC	VGNC:46472
Rattus norvegicus	SLC7A11	RGD	RGD:1309275
Bos taurus	SLC7A11	VGNC	VGNC:34926
Macaca mulatta	SLC7A11	VGNC	VGNC:77628
Felis catus	SLC7A11	VGNC	VGNC:65423
Others	SLC7A11	NCBI