GPX4-IN-21
GPX4-IN-21 (Compound 4d) is a selective glutathione peroxidase 4 (GPX4) inhibitor. GPX4-IN-21 can induce ferroptosis and downregulate the ferroptosis-related proteins SLC7A11, SLC11A2 and GPX4 levels. GPX4-IN-21 can induce ROS and MDA accumulation GPX4-IN-21 exhibits potent anti-proliferative activity. GPX4-IN-21 can be used for the research of cancer, such as melanoma.
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- CAS No.: 3014384-72-3
- Formule: C23H16ClN5O3
- Masse moléculaire:445.86
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
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GPX4 |
GPX4-IN-21 can induce ROS and MDA accumulation GPX4-IN-21 exhibits potent anti-proliferative activity against melanoma with an IC50 of 9.42 μM in A375 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3014384-72-3
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Masse moléculaire 445.86
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Formule C23H16ClN5O3
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SMILES
ClC1=CC(N2N=NC(C3=CC(C(NC4=CC=C(OCC(N5)=O)C5=C4)=O)=CC=C3)=C2)=CC=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GPX4-IN-21 Related Classifications
HY-180199 Related Classifications
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