2. Apoptosis Metabolic Enzyme/Protease NF-κB Immunology/Inflammation
  3. Glutathione Peroxidase Ferroptosis Reactive Oxygen Species (ROS)
  4. GPX4-IN-21

GPX4-IN-21 (Compound 4d) is a selective glutathione peroxidase 4 (GPX4) inhibitor. GPX4-IN-21 can induce ferroptosis and downregulate the ferroptosis-related proteins SLC7A11, SLC11A2 and GPX4 levels. GPX4-IN-21 can induce ROS and MDA accumulation GPX4-IN-21 exhibits potent anti-proliferative activity. GPX4-IN-21 can be used for the research of cancer, such as melanoma.

For research use only. We do not sell to patients.

GPX4-IN-21

GPX4-IN-21 Chemical Structure

CAS No. : 3014384-72-3

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GPX4-IN-21 Related Antibodies

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Description

GPX4-IN-21 (Compound 4d) is a selective glutathione peroxidase 4 (GPX4) inhibitor. GPX4-IN-21 can induce ferroptosis and downregulate the ferroptosis-related proteins SLC7A11, SLC11A2 and GPX4 levels. GPX4-IN-21 can induce ROS and MDA accumulation GPX4-IN-21 exhibits potent anti-proliferative activity. GPX4-IN-21 can be used for the research of cancer, such as melanoma[1].

IC50 & Target[1]

GPX4

 

In Vitro

GPX4-IN-21 can induce ROS and MDA accumulation GPX4-IN-21 exhibits potent anti-proliferative activity against melanoma with an IC50 of 9.42 μM in A375 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GPX4-IN-21 Related Antibodies
Molecular Weight

445.86

Formula

C23H16ClN5O3
CAS No.
SMILES

ClC1=CC(N2N=NC(C3=CC(C(NC4=CC=C(OCC(N5)=O)C5=C4)=O)=CC=C3)=C2)=CC=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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GPX4-IN-21 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GPX4-IN-213014384-72-3Glutathione PeroxidaseFerroptosisReactive Oxygen Species (ROS)Inhibitorinhibitorinhibit

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