TIA1 - TIA1 cytotoxic granule associated RNA binding protein Gene
Also Known as WDM; ALS26; TIA-1
Species: Homo sapiens
About TIA1
This gene has 20 transcripts (splice variants), 346 orthologues, 36 paralogues and is associated with 3 phenotypes. Ubiquitous expression in endometrium (RPKM 25.4), ovary (RPKM 18.9) and 25 other tissues.
Summary
The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of Apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms has been found for this gene. [provided by RefSeq, May 2017]
TIA1 Products (20)
| mRNA | Protein | Name |
|---|---|---|
| NM_001351508.2 | NP_001338437.1 | cytotoxic granule associated RNA binding protein TIA1 isoform 3 |
| NM_001351509.2 | NP_001338438.1 | cytotoxic granule associated RNA binding protein TIA1 isoform 4 |
| NM_001351510.2 | NP_001338439.1 | cytotoxic granule associated RNA binding protein TIA1 isoform 5 |
| NM_001351511.1 | NP_001338440.1 | cytotoxic granule associated RNA binding protein TIA1 isoform 6 |
| NM_001351512.1 | NP_001338441.1 | cytotoxic granule associated RNA binding protein TIA1 isoform 7 |
| NM_001351513.1 | NP_001338442.1 | cytotoxic granule associated RNA binding protein TIA1 isoform 8 |
| NM_001351514.2 | NP_001338443.1 | cytotoxic granule associated RNA binding protein TIA1 isoform 9 |
| NM_001351515.2 | NP_001338444.1 | cytotoxic granule associated RNA binding protein TIA1 isoform 10 |
| NM_001351516.2 | NP_001338445.1 | cytotoxic granule associated RNA binding protein TIA1 isoform 11 |
| NM_001351517.2 | NP_001338446.1 | cytotoxic granule associated RNA binding protein TIA1 isoform 12 |
| NM_001351518.2 | NP_001338447.1 | cytotoxic granule associated RNA binding protein TIA1 isoform 13 |
| NM_001351519.2 | NP_001338448.1 | cytotoxic granule associated RNA binding protein TIA1 isoform 14 |
| NM_001351520.2 | NP_001338449.1 | cytotoxic granule associated RNA binding protein TIA1 isoform 15 |
| NM_001351521.2 | NP_001338450.1 | cytotoxic granule associated RNA binding protein TIA1 isoform 16 |
| NM_001351522.2 | NP_001338451.1 | cytotoxic granule associated RNA binding protein TIA1 isoform 17 |
| NM_001351523.2 | NP_001338452.1 | cytotoxic granule associated RNA binding protein TIA1 isoform 18 |
| NM_001351524.2 | NP_001338453.1 | cytotoxic granule associated RNA binding protein TIA1 isoform 19 |
| NM_001351525.2 | NP_001338454.1 | cytotoxic granule associated RNA binding protein TIA1 isoform 19 |
| NM_022037.4 | NP_071320.2 | cytotoxic granule associated RNA binding protein TIA1 isoform 1 |
| NM_022173.4 | NP_071505.2 | cytotoxic granule associated RNA binding protein TIA1 isoform 2 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables RNA binding |
IDA
IDA: Inferred from direct assay
|
8576255 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
7544399 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in protein localization to cytoplasmic stress granule |
IMP
IMP: Inferred from mutant phenotype
|
24965446 | GOA |
| involved in regulation of alternative mRNA splicing, via spliceosome |
IDA
IDA: Inferred from direct assay
|
14966131 | GOA |
| involved in regulation of mRNA splicing, via spliceosome |
IDA
IDA: Inferred from direct assay
|
7488725 | GOA |
| involved in stress granule assembly |
IDA
IDA: Inferred from direct assay
|
8576255 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in cytoplasm |
IDA
IDA: Inferred from direct assay
|
7488725 | GOA |
| located in cytoplasmic stress granule |
IDA
IDA: Inferred from direct assay
|
8576255 | GOA |
| located in nuclear stress granule |
IDA
IDA: Inferred from direct assay
|
21984414 | GOA |
| located in nucleus |
IDA
IDA: Inferred from direct assay
|
8576255 | GOA |
TIA1 Protein Structure
RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (9 - 77)
RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (108 - 178)
RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (216 - 280)
- 0
- 100
- 200
- 300
- 386 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
cytotoxic granule associated RNA binding protein TIA1 |
|
TIA1 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P81484 | TIA1 Antibody (YA1229) | IHC-P | Human |
| HY-P81484A | TIA1 Antibody (YA1229)(PBS only) | IHC-P | Human |
| HY-P84252 | TIA1 Antibody (YA3949) | IHC-P, ICC/IF, FC, ELISA | Human |
| HY-P84252A | TIA1 Antibody (YA3949)(PBS only) | IHC-P, ICC/IF, FC, ELISA | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Welander Distal Myopathy |
|
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| Amyotrophic Lateral Sclerosis 26 With Or Without Frontotemporal Dementia |
|
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| Panniculitis |
|
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| Peripheral T-Cell Lymphoma |
|
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| Mycosis Fungoides |
|
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| Primary Cutaneous Gamma-Delta T-Cell Lymphoma |
|
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| Hepatosplenic T-Cell Lymphoma |
|
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| Systemic Epstein-Barr Virus Positive T-Cell Lymphoma Of Childhood |
|
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| Lichen Sclerosus Et Atrophicus |
|
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| Reticulosarcoma |
|
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| Primary Cutaneous T-Cell Non-Hodgkin Lymphoma |
|
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| Frontotemporal Dementia |
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| Lymphoma |
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| Giardiasis |
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| Aggressive Nk-Cell Leukemia |
|
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| Lymphomatoid Granulomatosis |
|
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| Lethal Midline Granuloma |
|
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| Parasitic Ichthyosporea Infectious Disease |
|
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| Rhinosporidiosis |
|
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| Lateral Sclerosis |
|
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| Dementia |
|
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| Nasal Type Extranodal Nk/T-Cell Lymphoma |
|
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| Esophagus Lymphoma |
|
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| Multisystem Proteinopathy |
|
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| Lymphoma, Hodgkin, Classic |
|
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| Arthrogryposis, Distal, Type 1c |
|
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| B-Cell Lymphoma |
|
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| Breast Implant-Associated Anaplastic Large Cell Lymphoma |
|
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| Lymphoproliferative Syndrome |
|
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| Lymphocytic Gastritis |
|
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| Lymphoproliferative Syndrome, X-Linked, 1 |
|
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| Motor Neuron Disease |
|
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| Orbit Lymphoma |
|
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| B-Cell Expansion With Nfkb And T-Cell Anergy |
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| Myopathy |
|
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| Mature T-Cell And Nk-Cell Lymphoma |
|
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| Achalasia |
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| Childhood Lymphoma |
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| Gastrointestinal Lymphoma |
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| Follicular Mucinosis |
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| Muscular Atrophy |
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| Epithelial-Stromal Tgfbi Dystrophy |
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| Angioimmunoblastic T-Cell Lymphoma |
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| Lattice Corneal Dystrophy |
|
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| T-Cell Adult Acute Lymphocytic Leukemia |
|
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| Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1 |
|
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| Inclusion Body Myopathy With Paget Disease Of Bone And Frontotemporal Dementia |
|
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| Appendix Lymphoma |
|
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| Sezary'S Disease |
|
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| Amyotrophic Lateral Sclerosis 1 |
|
|
| Celiac Disease 1 |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Macaca mulatta | TIA1 | VGNC | VGNC:78353 |
| Felis catus | TIA1 | VGNC | VGNC:66181 |
| Bos taurus | TIA1 | VGNC | VGNC:35858 |
| Rattus norvegicus | TIA1 | RGD | RGD:1305742 |
| Canis familiaris | TIA1 | VGNC | VGNC:47363 |
| Mus musculus | TIA1 | MGD | MGI:107914 |
| Others | TIA1 | NCBI |