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NKD2 - NKD inhibitor of WNT signaling pathway 2 Gene

Also Known as Naked2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 85409

About NKD2

Cytogenetic location: 5p15.33 Genomic coordinates (GRCh38): 5:1,008,802-1,038,943 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 194 orthologues and 1 paralogue. Broad expression in lung (RPKM 6.0), skin (RPKM 2.9) and 15 other tissues.

Summary

This gene encodes a member of a family of proteins that function as negative regulators of Wnt receptor signaling through interaction with Dishevelled family members. The encoded protein participates in the delivery of transforming growth factor alpha-containing vesicles to the cell membrane. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

NKD2 Products (2)

mRNA	Protein	Name
NM_001271082.2	NP_001258011.1	protein naked cuticle homolog 2 isoform 2
NM_033120.4	NP_149111.1	protein naked cuticle homolog 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATPase binding	IPI IPI: Inferred from physical interaction	18504258	GOA
enables growth factor binding	IPI IPI: Inferred from physical interaction	15064403	GOA
enables molecular adaptor activity	EXP EXP: Inferred from Experiment	17045239	GOA
enables myosin heavy chain binding	IPI IPI: Inferred from physical interaction	18504258	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15064403	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	18757723	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Golgi vesicle fusion to target membrane	IMP IMP: Inferred from mutant phenotype	17553928	GOA
involved in negative regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	20177058	GOA
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	15687260	GOA
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	20177058	GOA
involved in positive regulation of protein localization to plasma membrane	IDA IDA: Inferred from direct assay	15064403	GOA
involved in positive regulation of protein processing	IDA IDA: Inferred from direct assay	15064403	GOA
involved in protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	17553928	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	17553928	GOA
located in cell periphery	IDA IDA: Inferred from direct assay	15064403	GOA
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	15064403	GOA
located in exocytic vesicle	IDA IDA: Inferred from direct assay	18504258	GOA
located in lateral plasma membrane	IDA IDA: Inferred from direct assay	20177058	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	18504258	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
protein naked cuticle homolog 2	Dvl-binding protein NKD2

NKD2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NKD2	Q969F2	TGFA	Homo sapiens	P01135	Y2H	15064403
Intra	NKD2	Q969F2	RNF25	Homo sapiens	Q96BH1	Anti Bait CoIP	18757723
Intra	NKD2	Q969F2	RNF25	Homo sapiens	Q96BH1	Anti Tag CoIP	18757723

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09318	NKD2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	NKD2	VGNC	VGNC:63814
Rattus norvegicus	NKD2	RGD	RGD:1311459
Macaca mulatta	NKD2	VGNC	VGNC:75199
Mus musculus	NKD2	MGD	MGI:1919543
Bos taurus	NKD2	VGNC	VGNC:59353
Canis familiaris	NKD2	VGNC	VGNC:54105
Others	NKD2	NCBI