ABCB1-IN-2
ABCB1-IN-2 (compound 16q) is a functional inhibitor that can directly bind to the ABCB1 protein and stabilize its structure without affecting the expression and subcellular localization of ABCB1. ABCB1-IN-2 can increase the sensitivity of MCF-7/ADR cells to paclitaxel (PTX), increase the accumulation of PTX, and prevent the accumulation and excretion of luciferin Rh123 mediated by ABCB1. ABCB1-IN-2, as an ABCB1-mediated multidrug resistance (MDR) reversal agent, shows a strong ability to reverse MDR.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C29H29N3O6S
- 分子量:547.62
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
ABCB1[1]
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | IC50 |
>20 μM
Compound: 16q
|
Antiproliferative activity against human MCF7 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells incubated for 72 hrs by MTT assay
|
[PMID: 39151276] |
| MCF7 | IC50 |
2.65 nM
Compound: 16q
|
Reversal of paclitaxel resistance in human MCF7 cells assessed as reduction in paclitaxel IC50 at 10 uM pretreated with compound for 4 hrs followed by paclitaxel addition and measured after 72 hrs by MTT assay (Rvb = 2.60 +/- 0.36 nM)
Reversal of paclitaxel resistance in human MCF7 cells assessed as reduction in paclitaxel IC50 at 10 uM pretreated with compound for 4 hrs followed by paclitaxel addition and measured after 72 hrs by MTT assay (Rvb = 2.60 +/- 0.36 nM)
|
[PMID: 39151276] |
| MCF7 | IC50 |
2.96 nM
Compound: 16q
|
Reversal of paclitaxel resistance in human MCF7 cells assessed as reduction in paclitaxel IC50 at 5 uM pretreated with compound for 4 hrs followed by paclitaxel addition and measured after 72 hrs by MTT assay (Rvb = 2.60 +/- 0.36 nM)
Reversal of paclitaxel resistance in human MCF7 cells assessed as reduction in paclitaxel IC50 at 5 uM pretreated with compound for 4 hrs followed by paclitaxel addition and measured after 72 hrs by MTT assay (Rvb = 2.60 +/- 0.36 nM)
|
[PMID: 39151276] |
| NCI/ADR-RES | IC50 |
>20 μM
Compound: 16q
|
Antiproliferative activity against human MCF7ADR cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human MCF7ADR cells incubated for 72 hrs by MTT assay
|
[PMID: 39151276] |
| NCI/ADR-RES | IC50 |
0.027 μM
Compound: 16q
|
Reversal of paclitaxel resistance in human MCF7ADR cells assessed as reduction in paclitaxel IC50 at 5 uM pretreated with compound for 4 hrs followed by paclitaxel addition and measured after 72 hrs by MTT assay (Rvb = 6.68 +/- 0.35 microM)
Reversal of paclitaxel resistance in human MCF7ADR cells assessed as reduction in paclitaxel IC50 at 5 uM pretreated with compound for 4 hrs followed by paclitaxel addition and measured after 72 hrs by MTT assay (Rvb = 6.68 +/- 0.35 microM)
|
[PMID: 39151276] |
| NCI/ADR-RES | IC50 |
10.07 nM
Compound: 16q
|
Reversal of paclitaxel resistance in human MCF7ADR cells assessed as reduction in paclitaxel IC50 at 10 uM pretreated with compound for 4 hrs followed by paclitaxel addition and measured after 72 hrs by MTT assay (Rvb = 6.68 +/- 0.35 microM)
Reversal of paclitaxel resistance in human MCF7ADR cells assessed as reduction in paclitaxel IC50 at 10 uM pretreated with compound for 4 hrs followed by paclitaxel addition and measured after 72 hrs by MTT assay (Rvb = 6.68 +/- 0.35 microM)
|
[PMID: 39151276] |
化学情報
-
分子量 547.62
-
分子式 C29H29N3O6S
-
SMILES
COC1=C(OC)C(OC)=CC(C2=C(C3=CC(OC)=C(OC)C(OC)=C3)C(C)=NC4=CC(C5=CC=CS5)=NN24)=C1
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
ABCB1-IN-2 関連分類
HY-163981 関連分類
Powered by Bioz