Betulonaldehyde
Betulonaldehyde is a pentacyclic triterpenoid that can be isolated from Diospyros filipendula. Betulonaldehyde has antiplasmodial activity (IC50: 3.36 µg/mL). Betulonaldehyde has cytotoxic to NCI H187 lung cancer cells and non-cancerous Vero cells (IC50s: 19.23 and 17.09 µg/mL, respectively). Betulonaldehyde inhibits Phorbol 12-myristate 13-acetate (HY-18739) induced inflammation in mice.
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- CAS 番号: 4439-98-9
- 分子式: C30H46O2
- 分子量:438.69
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| B16 | ED50 |
0.35 μM
Compound: 10
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Induction of melanogenesis in mouse B16 2F2 cells assessed as intracellular melanin content after 3 days
Induction of melanogenesis in mouse B16 2F2 cells assessed as intracellular melanin content after 3 days
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[PMID: 12027734] |
| B16 | IC50 |
4.1 μM
Compound: 10
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Growth inhibition of mouse B16 2F2 cells after 3 days
Growth inhibition of mouse B16 2F2 cells after 3 days
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[PMID: 12027734] |
| H9 | EC50 |
45.6 μM
Compound: 30
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Anti-HIV activity against acutely infected H9 lymphocytes. Activity expressed as concentration of compound able to suppress HIV replication by 50%.
Anti-HIV activity against acutely infected H9 lymphocytes. Activity expressed as concentration of compound able to suppress HIV replication by 50%.
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[PMID: 9804704] |
| H9 | IC50 |
49 μM
Compound: 30
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Anti-HIV activity against acutely infected H9 lymphocytes. Activity expressed as concentration of compound toxic to 50% of mock-infected H9 cells.
Anti-HIV activity against acutely infected H9 lymphocytes. Activity expressed as concentration of compound toxic to 50% of mock-infected H9 cells.
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[PMID: 9804704] |
| KB | ED50 |
12.9 μg/mL
Compound: 7
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Cytotoxicity against human epidermoid carcinoma of the mouth (KB) cell line.
Cytotoxicity against human epidermoid carcinoma of the mouth (KB) cell line.
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[PMID: 9873420] |
| MT2 | CC50 |
20 μM
Compound: 38
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Cytotoxicity against mock-infected human MT2 cells assessed as reduction in cell viability incubated for 48 hrs by cell-titer Glo assay
Cytotoxicity against mock-infected human MT2 cells assessed as reduction in cell viability incubated for 48 hrs by cell-titer Glo assay
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[PMID: 25927586] |
| MT2 | IC50 |
4.2 μM
Compound: 38
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Antiviral activity against HIV1 NL4.3-Ren infected in human MT2 cells assessed as inhibition of viral growth measured 48 hrs post infection by luminometry
Antiviral activity against HIV1 NL4.3-Ren infected in human MT2 cells assessed as inhibition of viral growth measured 48 hrs post infection by luminometry
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[PMID: 25927586] |
| SK-MEL-2 | ED50 |
7.4 μg/mL
Compound: 7
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Cytotoxicity against cultured human melanoma (MEL-2) cell line.
Cytotoxicity against cultured human melanoma (MEL-2) cell line.
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[PMID: 9873420] |
化学情報
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CAS 番号 4439-98-9
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分子量 438.69
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分子式 C30H46O2
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SMILES
O=C[C@]12[C@@]([C@@H](CC2)C(C)=C)([H])[C@]3([H])[C@]([C@]4([C@]([C@@]5([C@@](C(C)(C(CC5)=O)C)([H])CC4)C)([H])CC3)C)(CC1)C
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Wisetsai A, et al. Chemical constituents and their biological activities from the roots of diospyros filipendula. Nat Prod Res. 2021 Aug;35(16):2739-2743. [Content Brief]
[2]. Yasukawa K, et al. Some lupane-type triterpenes inhibit tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin. Phytomedicine. 1995 Apr;1(4):309-13. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Betulonaldehyde 関連分類
HY-N9475 関連分類
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