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製品番号: HY-126207

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CBN209350

CBN209350 is a selective KDM4 inhibitor with an IC₅₀ of 4 μM. CBN209350 exerts antiproliferative effects on prostate cancer cells. CBN209350 can be used for the research of prostate cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 726201-10-1
分子式: C₁₃H₁₂N₄O₃
分子量:272.26

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

CBN209350 構造式

CAS 番号: 726201-10-1

容量

価格（税別）

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数量

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Histone Demethylase アイソフォーム固有の製品をすべて表示 :

体外実験

CBN209350 exerts inhibitory effects with comparable potency against all tested KDM4 family subtypes, and exhibits moderate selectivity for KDM4 over KDM2A (IC₅₀ 120 μM) and PHF8 (IC₅₀ 30 μM)^[1].
CBN209350 (48 h) exerts cytostatic effects on LnCaP prostate cancer cells^[1].
CBN209350 (100 μM; 48 h) reduces the level of H3K9me3 in PC-3 prostate cancer cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

Human prostate cancer cell lines LnCaP, DU145, PC-3
Concentration:

Dose-response titration
Incubation Time:

48 h
Result:

Inhibited LnCaP cell viability with an IC₅₀ of 410 μM.
Did not reduce DU145 or PC-3 cell viability by 50% at concentrations up to 1000 μM (IC₅₀ >1000 μM for both cell lines).

ELISA Assay^[1]

Cell Line:

Human prostate cancer cell lines LnCaP, DU145, PC-3
Concentration:

100 μM
Incubation Time:

48 h
Result:

Did not alter global H3K9me3 levels relative to DMSO-treated control in LnCaP or DU145 cells.
Caused a significant decrease in global H3K9me3 levels relative to DMSO-treated control in PC-3 cells.

化学情報

CAS 番号 726201-10-1
分子量 272.26
分子式 C₁₃H₁₂N₄O₃
SMILES

O=C(OC)CC1=NN(C(=O)C1)C2=NC=3C=CC=CC3N2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Carter DM, et al. Identification of a Novel Benzimidazole Pyrazolone Scaffold That Inhibits KDM4 Lysine Demethylases and Reduces Proliferation of Prostate Cancer Cells. SLAS Discov. 2017;22(7):801-812. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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希釈計算機

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濃度 _(開始) 濃度 _(開始)

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濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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化学情報
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参考文献

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CBN209350

Histone Demethylase アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

CBN209350 関連分類

HY-126207 関連分類