COX-2-IN-68
COX-2-IN-69 is a selective, orally active COX-2 inhibitor with an IC50 of 0.82 μM. COX-2-IN-69 occupies the secondary pocket of COX-2, interacts with His90 and Arg513, and reduces the serum levels of PGE2, IL-1β and TNF-α. COX-2-IN-69 exerts anti-inflammatory activity in a rat paw edema model. COX-2-IN-69 can be used in inflammation-related research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C21H19BrN2O3
- 分子量:427.29
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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COX-2 0.82 μM (IC50) |
IL-1β |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague Dawley (male, 130-150 g, Carrageenan (HY-125474)-induced paw edema model)[1]
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Dosage:10 mg/kg
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Administration:p.o.; single dose
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Result:Produced edema percentages of 17.58% at 1 h, 14.22% at 2 h, and 13.89% at 3 h post-Carrageenan injection.
Reduced serum PGE2 levels by 61.48% compared to the Carrageenan control group.
Reduced serum IL-1β levels by 62.17% compared to the carrageenan control group.
Reduced serum TNF-α levels by 58.36% compared to the carrageenan control group.
Showed moderate desquamation of gastric mucosa, inflammatory cell infiltration of the submucosa layer, and vacuolar degeneration of gastric glands, with milder gastric effects than indomethacin.
化学情報
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分子量 427.29
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分子式 C21H19BrN2O3
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SMILES
CCOC1=C(O)C=CC(/C=C/C2=NNC(C(CC3=CC=C(Br)C=C3)=C2)=O)=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
COX-2-IN-68 関連分類
HY-184709 関連分類
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