Ppp1r15a - protein phosphatase 1, regulatory subunit 15A Gene

Also Known as Gadd34; Myd116; 9630030H21

生物種: Mus musculus

遺伝子タイプ: protein coding

遺伝子ID: 17872

Summary

Enables protein Phosphatase binding activity and protein Phosphatase regulator activity. Involved in several processes, including peptidyl-serine dephosphorylation; regulation of gene expression; and regulation of protein modification process. Acts upstream of or within endoplasmic reticulum unfolded protein response. Predicted to be located in several cellular components, including Golgi apparatus; cytosol; and mitochondrion. Predicted to be part of protein Phosphatase type 1 complex. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including central nervous system; genitourinary system; gut; hemolymphoid system gland; and liver. Used to study thalassemia. Orthologous to human PPP1R15A (protein Phosphatase 1 regulatory subunit 15A). [provided by Alliance of Genome Resources, Apr 2022]

Ppp1r15a Products (1)

mRNA	Protein	Name
NM_008654.2	NP_032680.1	protein phosphatase 1 regulatory subunit 15A

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein phosphatase binding	IDA IDA: Inferred from direct assay	11381086	MGI
enables protein phosphatase regulator activity	IDA IDA: Inferred from direct assay	11381086	MGI

Biological Process GO Annotation	Evidence	参考文献	由来
acts upstream of or within endoplasmic reticulum unfolded protein response	IMP IMP: Inferred from mutant phenotype	15601821	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11381086	MGI
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	14635196	MGI
involved in positive regulation of peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	14635196	MGI
involved in positive regulation of transcription by RNA polymerase I	IDA IDA: Inferred from direct assay	14635196	MGI
involved in regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation	IDA IDA: Inferred from direct assay	11381086	MGI
involved in response to endoplasmic reticulum stress	IDA IDA: Inferred from direct assay	11381086	MGI
involved in response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	15601821	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
protein phosphatase 1 regulatory subunit 15A	growth arrest and DNA damage-inducible protein GADD34 growth arrest and DNA-damage-inducible 34 myeloid differentiation primary response gene 116 myeloid differentiation primary response protein MyD116 protein phosphatase 1, regulatory (inhibitor) sub

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Phase
HY-110365	Icerguastat Carbonate	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (7)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-111022	Icerguastat	Inhibitor	99.93%	Yes
HY-18956	(E/Z)-Icerguastat	Inhibitor	99.44%	Unkown
HY-RS10986	PPP1R15A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-18956B	(E/Z)-Icerguastat acetate	Inhibitor	/	Unkown
HY-18956A	(E/Z)-Icerguastat hydrochloride	Inhibitor	/	Unkown
HY-RS17569	Ppp1r15a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24029	Ppp1r15a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Homo sapiens	Ppp1r15a	NCBI	NCBI:23645