NCF2 - neutrophil cytosolic factor 2 Gene
Also Known as NCF-2; NOXA2; P67PHOX; P67-PHOX
生物種: Homo sapiens
About NCF2
This gene has 12 transcripts (splice variants), 203 orthologues, 1 paralogue and is associated with 3 phenotypes. Broad expression in bone marrow (RPKM 41.9), appendix (RPKM 36.2) and 15 other tissues.
Summary
This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH Oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH Oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2010]
NCF2 Products (5)
| mRNA | Protein | Name |
|---|---|---|
| NM_000433.4 | NP_000424.2 | neutrophil cytosol factor 2 isoform 1 |
| NM_001127651.3 | NP_001121123.1 | neutrophil cytosol factor 2 isoform 1 |
| NM_001190789.2 | NP_001177718.1 | neutrophil cytosol factor 2 isoform 3 |
| NM_001190794.2 | NP_001177723.1 | neutrophil cytosol factor 2 isoform 2 |
| NM_001410895.1 | NP_001397824.1 | neutrophil cytosol factor 2 isoform 4 |
| Molecular Function GO Annotation | Evidence | 参考文献 | 由来 |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
7938008 | GOA |
| enables superoxide-generating NADPH oxidase activator activity |
IMP
IMP: Inferred from mutant phenotype
|
8280052 | GOA |
| Biological Process GO Annotation | Evidence | 参考文献 | 由来 |
|---|---|---|---|
| involved in superoxide anion generation |
IMP
IMP: Inferred from mutant phenotype
|
8280052 | GOA |
| Cellular Component GO Annotation | Evidence | 参考文献 | 由来 |
|---|---|---|---|
| part of NADPH oxidase complex |
IDA
IDA: Inferred from direct assay
|
8280052 | GOA |
| located in cytosol |
IDA
IDA: Inferred from direct assay
|
8280052 | GOA |
| located in membrane |
IDA
IDA: Inferred from direct assay
|
8280052 | GOA |
NCF2 Protein Structure
TPR_11: TPR repeat (41 - 98)
SH3_1: SH3 domain (246 - 291)
PB1: PB1 domain (352 - 427)
SH3_1: SH3 domain (464 - 507)
- 0
- 100
- 200
- 300
- 400
- 500
- 526 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
neutrophil cytosol factor 2 |
|
NCF2 Protein-protein interaction Information
|
Type
|
タンパク質名 | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | 参考文献 |
|---|---|---|---|---|---|---|---|
|
Intra
|
NCF2 | P19878 | NCF4 | Homo sapiens | Q15080 | 16782902 | |
|
Intra
|
NCF2 | P19878 | GNAI2 | Homo sapiens | P04899 | 16782902 | |
|
Intra
|
NCF2 | P19878 | GNAI2 | Homo sapiens | P04899 | 16782902 | |
|
Intra
|
NCF2 | P19878 | GNB1 | Homo sapiens | P62873 | 16782902 | |
|
Intra
|
NCF2 | P19878 | NCF1 | Homo sapiens | P14598 | 12169629 | |
|
Intra
|
NCF2 | P19878 | NCF1 | Homo sapiens | P14598 | 16297854 | |
|
Intra
|
NCF2 | P19878 | NCF1 | Homo sapiens | P14598 | 15657040 | |
|
Intra
|
NCF2 | P19878 | NCF1 | Homo sapiens | P14598 | 16297854 | |
|
Intra
|
NCF2 | P19878 | NCF1 | Homo sapiens | P14598 | 16782902 | |
|
Intra
|
NCF2 | P19878 | GOLGA2 | Homo sapiens | Q08379 | 25910212 | |
|
Intra
|
NCF2 | P19878 | GOLGA2 | Homo sapiens | Q08379 | 25416956 | |
|
Intra
|
NCF2 | P19878 | GOLGA2 | Homo sapiens | Q08379 | 26871637 | |
|
Intra
|
NCF2 | P19878 | GOLGA2 | Homo sapiens | Q08379 | 25910212 | |
|
Intra
|
NCF2 | P19878 | GOLGA2 | Homo sapiens | Q08379 | 26871637 | |
|
Intra
|
NCF2 | P19878 | GOLGA2 | Homo sapiens | Q08379 | 25416956 | |
|
Intra
|
NCF2 | P19878 | GOLGA2 | Homo sapiens | Q08379 | 26871637 | |
|
Intra
|
NCF2 | P19878 | GOLGA2 | Homo sapiens | Q08379 | 25910212 | |
|
Intra
|
NCF2 | P19878 | PRKCD | Homo sapiens | Q05655 | 15591124 | |
|
Intra
|
NCF2 | P19878 | PRKCD | Homo sapiens | Q05655 | 15591124 | |
|
Intra
|
NCF2 | P19878 | KIFAP3 | Homo sapiens | Q92845 | 25910212 | |
|
Intra
|
NCF2 | P19878 | KIFAP3 | Homo sapiens | Q92845 | 32296183 | |
|
Intra
|
NCF2 | P19878 | KIFAP3 | Homo sapiens | Q92845 | 25416956 | |
|
Intra
|
NCF2 | P19878 | KIFAP3 | Homo sapiens | Q92845 | 26871637 | |
|
Intra
|
NCF2 | P19878 | KIFAP3 | Homo sapiens | Q92845 | 32296183 | |
|
Intra
|
NCF2 | P19878 | KIFAP3 | Homo sapiens | Q92845 | 26871637 | |
|
Intra
|
NCF2 | P19878 | KIFAP3 | Homo sapiens | Q92845 | 25416956 | |
|
Intra
|
NCF2 | P19878 | KIFAP3 | Homo sapiens | Q92845 | 25910212 | |
|
Intra
|
NCF2 | P19878 | KIFAP3 | Homo sapiens | Q92845 | 26871637 | |
|
Intra
|
NCF2 | P19878 | KIFAP3 | Homo sapiens | Q92845 | 32296183 | |
|
Intra
|
NCF2 | P19878 | KIFAP3 | Homo sapiens | Q92845 | 25416956 | |
|
Intra
|
NCF2 | P19878 | KIFAP3 | Homo sapiens | Q92845 | 21516116 | |
|
Intra
|
NCF2 | P19878 | KIFAP3 | Homo sapiens | Q92845 | 25910212 |
Recombinant NCF2 Proteins
| 製品番号 | 製品名 | アクセッション番号 | 純度 |
|---|---|---|---|
| HY-P74655 | p67phox Protein, Human (sf9, His-GST) | P19878 (M1-V526) | ≥ 90%, as determined by reducing SDS-PAGE. |
| HY-P74656 | p67phox Protein, Human (sf9) | P19878 (N-G&P, M1-V526) | ≥ 85%, as determined by reducing SDS-PAGE. |
NCF2 抗体
| 製品番号 | 製品名 | アプリケーション | 反応性 |
|---|---|---|---|
| HY-P81904 | NOXA2 Antibody (YA1649) | WB, IHC-P, ICC/IF, IP | Human, Mouse, Rat |
関連疾患
| Diseases | Alias | |
|---|---|---|
| Granulomatous Disease, Chronic, Autosomal Recessive, 2 |
|
|
| Chronic Granulomatous Disease |
|
|
| Phagocyte Bactericidal Dysfunction |
|
|
| Granulomatous Disease, Chronic, Autosomal Recessive, 1 |
|
|
| Granulomatous Disease, Chronic, X-Linked |
|
|
| Lung Abscess |
|
|
| Suppurative Lymphadenitis |
|
|
| Splenic Abscess |
|
|
| Ectodermal Dysplasia |
|
|
| Gastrointestinal Defects And Immunodeficiency Syndrome 1 |
|
|
| Lung Disease |
|
|
| Malignant Secondary Hypertension |
|
|
| Hypertension, Essential |
|
|
| Alzheimer Disease, Familial, 1 |
|
|
Orthologs Information
| 生物種 | Symbol | 由来 | ID |
|---|---|---|---|
| Bos taurus | NCF2 | VGNC | VGNC:31912 |
| Felis catus | NCF2 | VGNC | VGNC:68425 |
| Rattus norvegicus | NCF2 | RGD | RGD:1309424 |
| Macaca mulatta | NCF2 | VGNC | VGNC:75140 |
| Mus musculus | NCF2 | MGD | MGI:97284 |
| Canis familiaris | NCF2 | VGNC | VGNC:43650 |
| Others | NCF2 | NCBI |