THY1 - Thy-1 cell surface antigen Gene

Also Known as CD90; CDw90

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 7070

About THY1

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:119,415,476-119,424,985 (from NCBI)

This gene has 10 transcripts (splice variants) and 130 orthologues. Broad expression in brain (RPKM 87.8), kidney (RPKM 58.0) and 16 other tissues.

Summary

This gene encodes a cell surface glycoprotein and member of the immunoglobulin superfamily of proteins. The encoded protein is involved in cell adhesion and cell communication in numerous cell types, but particularly in cells of the immune and nervous systems. The encoded protein is widely used as a marker for hematopoietic stem cells. This gene may function as a tumor suppressor in nasopharyngeal carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

THY1 Products (4)

mRNA Protein Name
NM_001311160.2 NP_001298089.1 thy-1 membrane glycoprotein isoform 1 preproprotein
NM_001311162.2 NP_001298091.1 thy-1 membrane glycoprotein isoform 1 preproprotein
NM_001372050.1 NP_001358979.1 thy-1 membrane glycoprotein isoform 2 precursor
NM_006288.5 NP_006279.2 thy-1 membrane glycoprotein isoform 1 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables integrin binding IMP
IMP: Inferred from mutant phenotype
18346467 GOA
enables integrin binding IPI
IPI: Inferred from physical interaction
15004192 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
7513706 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in heterotypic cell-cell adhesion IDA
IDA: Inferred from direct assay
15004192 GOA
involved in integrin-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
18346467 GOA
involved in positive regulation of cellular extravasation IDA
IDA: Inferred from direct assay
15004192 GOA
involved in positive regulation of focal adhesion assembly IMP
IMP: Inferred from mutant phenotype
18346467 GOA
involved in regulation of cell-matrix adhesion IMP
IMP: Inferred from mutant phenotype
9749990 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in apical plasma membrane IDA
IDA: Inferred from direct assay
14757759 GOA
located in cell surface IDA
IDA: Inferred from direct assay
9749990 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

THY1 Protein Structure

ig

ig: Immunoglobulin domain (32 - 104)

  • 0
  • 100
  • 161 a.a.
Protein Preferred Names Protein Names

thy-1 membrane glycoprotein

  • Thy-1 T-cell antigen

THY1 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
THY1 P04216 APP Homo sapiens P05067
Validated Y2H
32814053
Intra
THY1 P04216 APP Homo sapiens P05067
Y2H Array
32814053
Intra
THY1 P04216 APP Homo sapiens P05067
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant THY1 Proteins

製品番号 製品名 アクセッション番号 純度
HY-P74516 Thy1/CD90 Protein, Human (HEK293, His) P04216 (Q20-C130) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P74517 Thy1/CD90 Protein, Human (HEK293, Fc) P04216 (Q20-C130) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P74518 Thy1/CD90 Protein, Human (HEK293) P04216/NP_006279.2(Q20-C130) ≥ 95%, as determined by reducing SDS-PAGE.

THY1 抗体

製品番号 製品名 アプリケーション 反応性
HY-P80069 CD90/Thy-1 Antibody (YA523) WB, IHC-P Human, Rat
HY-P81132 CD90/Thy-1 Antibody WB, IHC-P, ICC/IF Human
HY-P83940 CD90/Thy-1 Antibody (YA3637) WB, IHC-P, ICC/IF, ELISA Human, Rat
HY-P83940A CD90/Thy-1 Antibody (YA3637)(PBS only) WB, IHC-P, ICC/IF, ELISA Human, Rat
HY-P85011 CD90/Thy-1 Antibody (YA4703) ELISA, FC Human
HY-P86097 CD90/Thy-1 Antibody (YA5789) WB, IHC-P, ICC/IF, ELISA Human, Mouse

関連疾患

Diseases Alias
Retinal Artery Occlusion

  • Retina Artery Narrowing

  • Retinal Artery Spasm

  • Spasm Of Ophthalmic Artery

  • Retinal Spasm

  • Vasospasm Of Retina
Thymoma

  • Primary Thymic Epithelial Neoplasm

  • Primary Thymic Epithelial Tumor

  • Thymus Neoplasms
Nasopharyngeal Carcinoma

  • Malignant Neoplasm Of Nasopharynx

  • Npc

  • Nasopharyngeal Cancer

  • Nasopharyngeal Carcinoma 1

  • Nasopharynx Carcinoma

  • Nasopharyngeal Neoplasms

  • Npca

  • Carcinoma Of Nasopharynx

  • Malignant Nasopharyngeal Tumor

  • Nasopharynx Cancer

  • Squamous Cell Carcinoma Of The Nasopharynx

  • Nasopharyngeal Neoplasm

  • Cancer Of Nasopharynx
Mesangial Proliferative Glomerulonephritis

  • Glomerulonephritis - Mesangial Proliferative

  • Mesangial Proliferative Gn

  • Mesangioproliferative Glomerulonephritis

  • Glomerulonephritis Mesangial Proliferative
Acute Leukemia

  • Stem Cell Leukaemia

  • Stem Cell Leukemia

  • Acute Leukemias

  • Acute Undifferentiated Leukemia

  • Undifferentiated Leukemia

  • Acute Leukaemia Of Unspecified Cell Type Without Mention Of Remission

  • Blast Cell Leukaemia

  • Blast Leukaemia

  • Blastic Leukaemia

  • Undifferentiated Leukaemia
Adhesions Of Uterus

  • Intrauterine Adhesions

  • Intrauterine Synechiae

  • Band Of Uterus

  • Asherman Syndrome

  • Internal Adhesion Of Uterus

  • Internal Band Of Uterus
Anal Fistula

  • Anorectal Fistula

  • Rectal Fistula

  • Allingham Ulcer

  • Perianal Fistula

  • Fistula In Ano

  • Anorectum Fistula
Dental Pulp Disease

  • Dental Pulp Diseases

  • Dental Pulp Disorder

  • Disorder Of Pulp Of Tooth

  • Pulp Disorder
Dental Pulp Necrosis

  • Pulp Necrosis

  • Necrotic Pulp

  • Necrosis Of The Pulp

  • Dead Pulp

  • Devitalised Pulp

  • Putrescent Pulpitis

  • Devitalized Tooth

  • Dental Pulp Gangrene

  • Pulp Gangrene

  • Nonvital Tooth

  • Pulpless Tooth

  • Putrescent Pulp
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Limb Ischemia
Germ Cell And Embryonal Cancer

  • Germ Cell And Embryonal Neoplasm
Tibial Nerve Palsy
Cartilage Disease

  • Cartilage Diseases

  • Cartilage

  • Cartilage Disorder

  • Chondropathy

  • Cartilage Disorders
Germ Cell Cancer

  • Malignant Germ Cell Tumor

  • Neoplasms, Germ Cell And Embryonal

  • Germ Cell Neoplasm

  • Germ Cell Tumour

  • Malignant Tumor Of The Germ Cell

  • Neoplasms Germ Cell

  • Malignant Germ Cell Neoplasm
Leukemia, Acute Lymphoblastic

  • Acute Lymphoblastic Leukemia

  • ALL

  • Acute Lymphocytic Leukemia

  • Leukemia, Acute Lymphocytic, Susceptibility To, 1

  • Acute Lymphoblastic Leukaemia

  • Precursor Lymphoblastic Lymphoma/Leukemia

  • Precursor Lymphoid Neoplasm

  • Leukemia, Acute Lymphoblastic, Susceptibility To

  • B-Cell Acute Lymphoblastic Leukemia

  • Leukemia, Acute Lymphocytic 1

  • Acute Lymphocytic Leukaemia

  • Acute Lymphoblastic Leukemia/Lymphoma

  • All1

  • Childhood Acute Lymphoblastic Leukemia

  • Leukemia Acute Lymphoblastic 1

  • Leukemia Acute Lymphoblastic B-Hyperdiploid

  • Leukemia Acute Lymphocytic

  • Leukemia Acute Lymphocytic 1

  • Leukemia B-Cell Acute Lymphoblastic

  • Leukemia T-Cell Acute Lymphoblastic

  • Leukemia, Acute Lymphoblastic, 3

  • ALL3

  • Lymphoblastic Leukemia Acute

  • Leukemia, Acute, Lymphoblastic

  • Precursor Cell Lymphoblastic Leukemia Lymphoma

  • Leukemia, Lymphocytic, Acute, L1

  • Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Inflammatory Bowel Disease 14

  • IBD14

  • Inflammatory Bowel Disease 14, Susceptibility To

  • Bowel Disease, Inflammatory, Type 14
Spinocerebellar Ataxia 45

  • SCA45

  • Spinocerebellar Ataxia Type 45
Brittle Bone Disorder

  • Osteogenesis Imperfecta

  • Brittle Bone Disease

  • Fragilitas Ossium

  • Osteopsathyrosis

  • Lobstein Disease

  • Oi

  • Vrolik Disease

  • Lobstein'S Disease

  • Lobstein'S Syndrome

  • Vrolik'S Disease

  • Porak And Durante Disease

  • Glass Bone Disease

  • Osteogenesis Imperfecta, Dominant Perinatal Lethal

  • Osteogenesis Imperfecta, Recessive Perinatal Lethal

  • Brittle Bone Syndrome

  • Oi - [Osteogenesis Imperfecta]

  • Ossium Fragility

  • Osteitis Fragilitans

  • Bony Fragility

  • Blue Sclera With Fragility Of Bone And Deafness

  • White Blue Sclera - Fragility Of Bone - Deafness
Epilepsy, Familial Temporal Lobe, 2

  • Familial Temporal Lobe Epilepsy 2

  • Temporal Epilepsy, Familial

  • ETL2

  • Ftle

  • Epilepsy, Familial Temporal Lobe

  • Familial Temporal Lobe Epilepsy
Severe Combined Immunodeficiency

  • Scid

  • Severe Combined Immunodeficiency Disease

  • Combined T And B Cell Inborn Immunodeficiency

  • Immunodeficiency, Severe Combined

  • Scid - [Severe Combined Immunodeficiencies]
Interstitial Lung Disease 2

  • Idiopathic Pulmonary Fibrosis

  • Ipf

  • Fibrocystic Pulmonary Dysplasia

  • Pulmonary Fibrosis, Idiopathic

  • Pulmonary Fibrosis, Idiopathic, Susceptibility To

  • Cryptogenic Fibrosing Alveolitis

  • ILD2

  • Idiopathic Pulmonary Fibrosis, Familial

  • Fibrosing Alveolitis, Cryptogenic

  • Uip

  • Fibrosing Alveolitis

  • Interstitial Pneumonitis, Usual

  • Familial Idiopathic Pulmonary Fibrosis

  • Idiopathic Fibrosing Alveolitis, Chronic Form

  • Usual Interstitial Pneumonia

  • Fibrosing Alveolitis Cryptogenic

  • Hamman-Rich Disease

  • Idiopathic Pulmonary Fibrosis Familial

  • Interstitial Pneumonitis Usual

  • Fibrosis Idiopathic Pulmonary

  • Fibrosis, Pulmonary, Idiopathic

  • Hamman-Rich Syndrome

  • Chronic Idiopathic Pulmonary Fibrosis

  • Acute Interstitial Pneumonia

  • Interstitial Pulmonary Fibrosis

  • Ipf - [Idiopathic Pulmonary Fibrosis]

  • Idiopathic Lung Fibrosis

  • Fibrosing Lung Disease

  • Pulmonary Fibrosis Nos

  • Fibrosing Pneumonitis
Osteochondrodysplasia

  • Skeletal Dysplasia

  • Chondrodystrophy

  • Congenital Anomaly Of Cartilage

  • Osteochondrodysplasias

  • Cartilage Development Disorder

  • Osteochondrodysplasia Syndrome

  • Dysplasia, Skeletal

  • Mucopolysaccharidosis Iv
Connective Tissue Disease

  • Connective Tissue Diseases

  • Connective Tissue Disorder

  • Abnormality Of Connective Tissue

  • Disorder Of Connective Tissue

  • Connective Tissue Disorders
Nervous System Disease

  • Abnormality Of The Nervous System

  • Nervous System Diseases

  • Nervous System Disorder
Eye Disease

  • Eye Diseases

  • Abnormality Of The Eye

  • Toxoplasma Oculopathy
Amyotrophic Lateral Sclerosis 1

  • Amyotrophic Lateral Sclerosis

  • ALS

  • Lou Gehrig Disease

  • Amyotrophic Lateral Sclerosis Type 1

  • Charcot Disease

  • ALS1

  • Amyotrophic Lateral Sclerosis, Susceptibility To

  • Fals

  • Lou Gehrig'S Disease

  • Mnd

  • Motor Neuron Disease

  • Familial Amyotrophic Lateral Sclerosis

  • Amyotrophic Lateral Sclerosis 1, Familial

  • Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

  • Motor Neuron Disease, Bulbar

  • Motor Neurone Disease

  • Amyotrophic Lateral Sclerosis With Dementia

  • Dementia With Amyotrophic Lateral Sclerosis

  • Motor Neuron Disease, Amyotrophic Lateral Sclerosis

  • Sclerosis, Lateral, Amyotrophic

  • Sclerosis, Lateral, Amyotrophic, Type 1

  • Amyotrophic Sclerosis

  • Als - [Amyotrophic Lateral Sclerosis]

  • Wasting Palsy

  • Amyotrophic Paralysis

  • Amyotrophy Lateral Sclerosis

  • Wasting Paralysis

  • Spinal Progressive Amyotrophy

  • Progressive Atrophic Paralysis
Peripheral Nervous System Disease

  • Peripheral Neuropathy

  • Peripheral Nerve Disease

  • Peripheral Nerve Disorders

  • Neuropathy, Peripheral

  • Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Leukemia, Acute Myeloid

  • Acute Myeloid Leukemia

  • Leukemia, Acute Myelogenous

  • Acute Myelogenous Leukemia

  • AML

  • Leukemia, Acute Myeloid, Susceptibility To

  • Acute Myeloblastic Leukemia

  • Leukemia, Acute Myeloid, Reduced Survival In, Somatic

  • Acute Myeloid Leukaemia

  • Leukemia, Myelocytic, Acute

  • Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

  • Secondary Aml

  • Acute Myelocytic Leukemia

  • Acute Myeloid Leukemia, Somatic

  • Leukemia, Acute Myeloid, Somatic

  • Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

  • Acute Myeloblastic Leukaemia

  • Acute Myelogenous Leukaemia

  • Aml - Acute Myeloid Leukemia

  • Acute Myeloid Leukemia With Cebpa Somatic Mutations

  • Aml With Cebpa Somatic Mutations

  • Inherited Acute Myeloid Leukemia

  • Familial Aml

  • Inherited Aml

  • Pure Familial Aml

  • Pure Familial Acute Myeloid Leukemia

  • Secondary Acute Myeloid Leukemia

  • Therapy-Related Aml And Myelodysplastic Syndrome

  • Acute Myeloid Leukemia, Secondary

  • Acute Non-Lymphoblastic Leukemia

  • Acute Non-Lymphocytic Leukemia

  • Acute Biphenotypic Leukemia

  • Acute Undifferentiated Leukemia

  • Acute Myeloblastic Leukaemia With Multilineage Dysplasia

  • Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

  • Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Retinitis Pigmentosa

  • RP

  • Rod-Cone Dystrophy

  • Autosomal Recessive Retinitis Pigmentosa

  • Non-Syndromic Retinitis Pigmentosa

  • Pericentral Pigmentary Retinopathy

  • Pigmentary Retinopathy

  • Tapetoretinal Degeneration

  • Rcd

  • Retinitis Pigmentosa Autosomal Recessive

  • ARRP

  • Retinitis Pigmentosa, Autosomal Recessive

  • Retinitis Pigmentosa 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-12953 R-268712 Inhibitor 99.92% Unkown
HY-117738 Benarthin Inhibitor 95.79% Unkown
HY-RS14511 THY1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-106611 Brinazarone Inhibitor / Unkown
HY-RS17457 Thy1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23914 Thy1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
阻害性抗体 (2)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-P990157 Anti-Mouse Thy1/CD90 Antibody (M5/49.4.1) Inhibitor 95.00% Unkown
HY-P990156 Anti-Mouse Thy1.1/CD90.1 Antibody (19E12) Inhibitor 95.00% Unkown

Orthologs Information

生物種 Symbol 由来 ID
Macaca mulatta THY1 VGNC VGNC:78352
Rattus norvegicus THY1 RGD RGD:3860
Felis catus THY1 VGNC VGNC:104334
Canis familiaris THY1 VGNC VGNC:47362
Mus musculus THY1 MGD MGI:98747
Bos taurus THY1 VGNC VGNC:35856
Others THY1 NCBI