DSCC1 - DNA replication and sister chromatid cohesion 1 Gene

Also Known as DCC1

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 79075

About DSCC1

Cytogenetic location: 8q24.12 Genomic coordinates (GRCh38): 8:119,833,976-119,855,894 (from NCBI)

This gene has 2 transcripts (splice variants) and 204 orthologues. Ubiquitous expression in lymph node (RPKM 3.7), appendix (RPKM 2.3) and 24 other tissues.

Summary

CHTF18 (MIM 613201), CHTF8 (MIM 613202), and DSCC1 are components of an alternative replication factor C (RFC) (see MIM 600404) complex that loads PCNA (MIM 176740) onto DNA during S phase of the cell cycle (Merkle et al., 2003 [PubMed 12766176]; Bermudez et al., 2003 [PubMed 12930902]).[supplied by OMIM, Dec 2009]

DSCC1 Products (1)

mRNA	Protein	Name
NM_024094.3	NP_076999.2	sister chromatid cohesion protein DCC1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
contributes to DNA clamp loader activity	IDA IDA: Inferred from direct assay	12930902	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16682347	GOA
contributes to single-stranded DNA helicase activity	IDA IDA: Inferred from direct assay	12930902	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in maintenance of mitotic sister chromatid cohesion	IMP IMP: Inferred from mutant phenotype	16682347	GOA
involved in positive regulation of DNA-directed DNA polymerase activity	IDA IDA: Inferred from direct assay	12930902	GOA
involved in post-translational protein acetylation	IMP IMP: Inferred from mutant phenotype	19907496	GOA
involved in regulation of DNA replication	IMP IMP: Inferred from mutant phenotype	19907496	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
part of Ctf18 RFC-like complex	IDA IDA: Inferred from direct assay	12930902	GOA
located in chromatin	IDA IDA: Inferred from direct assay	16682347	GOA
located in chromosome, centromeric region	IDA IDA: Inferred from direct assay	16682347	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	16682347	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DSCC1 Protein Structure

Dcc1

0
100
200
300
393 a.a.

Protein Preferred Names	Protein Names
sister chromatid cohesion protein DCC1	defective in sister chromatid cohesion 1 homolog

DSCC1 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	DSCC1	Q9BVC3	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	DSCC1	Q9BVC3	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	DSCC1	Q9BVC3	FGFR3	Homo sapiens	P22607	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Diseases	Alias
Amelogenesis Imperfecta, Hypomaturation Type, Iia3	Amelogenesis Imperfecta Hypomaturation Type 2a3 AI2A3 Amelogenesis Imperfecta Hypomaturation Type Iia3 Amelogenesis Imperfecta, Type Iia3 Amelogenesis Imperfecta Type Iia3 Amelogenesis Imperfecta, Hypomaturation Type, 2a3
Cornelia De Lange Syndrome	De Lange Syndrome Brachmann De Lange Syndrome Brachmann-De Lange Syndrome Cdls Bdls Typus Degenerativus Amstelodamensis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS04019	DSCC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21561	Dscc1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28079	Dscc1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Canis familiaris	DSCC1	VGNC	VGNC:51769
Mus musculus	DSCC1	MGD	MGI:1919357
Bos taurus	DSCC1	VGNC	VGNC:28217
Felis catus	DSCC1	VGNC	VGNC:61636
Macaca mulatta	DSCC1	VGNC	VGNC:71894
Rattus norvegicus	DSCC1	RGD	RGD:1561749
Others	DSCC1	NCBI