Lobetyolinin
Based on 1 Customer Validation
Lobetyolinin is a polyacetylene compound. Lobetyolinin can be extracted from the traditional Chinese medicine Codonopsis pilosula. Lobetyolinin has antiarrhythmic effects. Lobetyolinin can be used in liver cancer research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.06%
- CAS 番号: 142451-48-7
- 分子式: C26H38O13
- 分子量:558.57
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保管条件:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
Lobetyolinin (50 µM; 24 h) significantly restores the heart rate of larvae and improves atrioventricular block in Terfenadine (HY-B1193)-induced arrhythmia model of Cmlc2-GFP transgenic zebrafish larvae[1].
Lobetyolinin (6 h) restores abnormal heart rate and rhythm in adult zebrafish model[1].
Lobetyolinin (up to 80 µM) shows no significant inhibitory effect on cell viability and does not induce apoptosis in HepG2 and Huh7 hepatocellular carcinoma cell models[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 142451-48-7
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性状 Solid
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分子量 558.57
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分子式 C26H38O13
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Color White to off-white
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SMILES
C/C=C/C#CC#C[C@@H](O)[C@@H](/C=C/CCCO)O[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1O)O)O)CO[C@@H]2O[C@@H]([C@H]([C@@H]([C@H]2O)O)O)CO
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
Ethanol : 6.67 mg/mL (11.94 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (273 KB)
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SDS (252 KB)
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- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Liu H, et al. Screening and Identification of Cardioprotective Compounds From Wenxin Keli by Activity Index Approach and in vivo Zebrafish Model. Front Pharmacol. 2018;9:1288. Published 2018 Nov 13. [Content Brief]
[2]. Hu J, et al. Lobetyolin Suppresses the Proliferation of Hepatocellular Carcinoma through Activating DUSP1-ERK1/2 Signaling Pathway. Biol Pharm Bull. 2024;47(10):1751-1758. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol | 1 mM | 1.7903 mL | 8.9514 mL | 17.9029 mL | 44.7571 mL |
| 5 mM | 0.3581 mL | 1.7903 mL | 3.5806 mL | 8.9514 mL | |
| 10 mM | 0.1790 mL | 0.8951 mL | 1.7903 mL | 4.4757 mL |
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