Moracin G
Moracin G is a plant-derived kinase modulator and receptor ligand that forms stable bindings with multiple key proteins (AKT1, COX2 and Estrogen receptor 1) and competitively inhibits the activity of specific kinases. By binding to MELK to disrupt cell cycle regulation, Moracin G impairs the survival and proliferation of cancer cells, induces cancer cell apoptosis, and thereby exerts anti-tumor potential. Moracin G can be used in research related to periodontitis and breast cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 73338-86-0
- 分子式: C19H16O4
- 分子量:308.33
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Akt1 |
COX-2 |
Moracin G meets the pharmacokinetic criteria for active ingredients, with an oral bioavailability of 75.78% and a drug-likeness score of 0.42[1].
Moracin G is a key active component in mulberry leaves that alleviates periodontitis, and it interacts with 37 different human targets associated with periodontitis. The top 10 key targets are IL-6, ALB, TNF, VEGFA, AKT1, TP53, PTGS2, EGF, MMP9, and IL-10, among which the binding affinity with AKT1 is -10.7 kcal/mol[1].
Moracin G exhibits favorable in silico ADMET properties, including high gastrointestinal absorption, low blood-brain barrier permeability, and no predicted toxicity, rendering it a viable candidate for further development[2].
Moracin G is predicted to have a high probability of acting as a kinase inhibitor, antineoplastic agent, apoptosis agonist, and antineoplastic agent against breast cancer[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 73338-86-0
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分子量 308.33
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分子式 C19H16O4
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SMILES
OC1=CC(O)=CC(C2=CC(C=CC3=C4CC=C(C)CO3)=C4O2)=C1
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Wu Z, et al. Exploring the pharmacological components and effective mechanism of Mori Folium against periodontitis using network pharmacology and molecular docking. Arch Oral Biol. 2022;139:105391. [Content Brief]
[2]. Prasad P, et al. Computational identification of Moracin G and Isolonchocarpin as potent MELK inhibitors for anticancer drug discovery. Sci Rep. 2025;16(1):397. Published 2025 Dec 6. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
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