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SGC0946 TFA

13 Cited Publications
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Based on 13 publication(s) in Google Scholar

SGC0946 TFA is a selective DOT1L inhibitor with an IC50 value of 0.3 nM. By inhibiting DOT1L, SGC0946 TFA can induce G1 phase arrest, suppress cell self-renewal and metastatic potential, and induce cell differentiation in cancer cells. SGC0946 TFA can be used in the research of tumors such as leukemia and breast cancer, and also serves as a probe to further investigate the cellular mechanisms of DOT1L in normal and diseased cells.

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  • 分子式: C30H41BrF3N7O6
  • 分子量:732.59
  • 保管条件:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • SGC0946 TFA Chemical Structure
    SGC0946 TFA 構造式
  • Experimental Validation Results for SGC0946 TFA
  • Experimental Validation Results for SGC0946 TFA
  • Experimental Validation Results for SGC0946 TFA
  • Experimental Validation Results for SGC0946 TFA
  • Experimental Validation Results for SGC0946 TFA
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  • SGC0946 TFA Chemical Structure
    SGC0946 TFA Chemical Structure
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  • 1/16

    SGC0946 TFA purchased from MedChemExpress. Usage Cited in: Sci Adv. 2023 Jun 2;9(22):eadc9273. [Abstract]

    Customer Validation
     CCK-8 assay data showing the sensitivity of NCI-H460-DOT1L-WT/R231Q cells to SGC0946 (0.01,.0.1, 1, 10, 100 μM, 6 days).

  • 1/16

    SGC0946 TFA purchased from MedChemExpress. Usage Cited in: Sci Adv. 2023 Jun 2;9(22):eadc9273. [Abstract]

    Customer Validation
     CDX-bearing mice were treated with vehicle Cisplatin (3 mg/kg, twice per week), Vinorelbine (4 mg/kg, twice per week), or SGC0946 (20 mg/kg, five times per week) through intraperitoneal administration. The graphs show the tumor images and weights, with the tumor inhibition rate.

  • 1/16

    SGC0946 TFA purchased from MedChemExpress. Usage Cited in: Sci Adv. 2023 Jun 2;9(22):eadc9273. [Abstract]

    Customer Validation
     Crystal violet staining of NCI-H460-DOT1L-WT/R231Q cells treated with SGC0946 (2.5 or 7.5 μM), binimetinib (2.5 or 7.5 μM), or the combination at the same concentrations for 7 to 14 days (top). Comparison of relative colony formation between groups at 7.5 μM drug concentration.

  • 1/16

    SGC0946 TFA purchased from MedChemExpress. Usage Cited in: Elife. 2020 Oct 1;9:e57858. [Abstract]

    Customer Validation
     Q-PCR analysis of the HOXA9P2A-mCherry cells with or without the 6-day treatment of the DOT1L inhibitor SGC0946 by using specific primers targeting the mRNA sequences of mCherry and HOXA9. The correlation of transcription reduction in mCherry and HOXA9 in response to inhibitor–mediated transcription repression was calculated by performing Pearson’s correlation test.

  • 1/16

    SGC0946 TFA purchased from MedChemExpress. Usage Cited in: Elife. 2020 Oct 1;9:e57858. [Abstract]

    Customer Validation
     Flow cytometry analysis of the HOXA9P2A-mCherry cells treated with DMSO and various dosages of the DOT1L inhibitor SGC0946 (1, 5 μM).

  • SGC0946 TFA