VU0364572
VU0364572 is a selective allosteric agonist of the M1 muscarinic receptor with an EC50 of 0.11 μM. VU0364572 has neuroprotective potential for preventing memory impairments and reducing neuropathology in Alzheimer’s Disease. VU0364572 is orally active and is CNS penetrant.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1240514-87-7
- 分子式: C21H31N3O3
- 分子量:373.49
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | EC50 |
>30 μM
Compound: 17, VU0364572
|
Agonist activity at rat muscarinic M2 receptor expressed in CHO cells
Agonist activity at rat muscarinic M2 receptor expressed in CHO cells
|
[PMID: 21930376] |
| CHO | EC50 |
>30 μM
Compound: 17, VU0364572
|
Agonist activity at rat muscarinic M3 receptor expressed in CHO cells
Agonist activity at rat muscarinic M3 receptor expressed in CHO cells
|
[PMID: 21930376] |
| CHO | EC50 |
>30 μM
Compound: 17, VU0364572
|
Agonist activity at rat muscarinic M4 receptor expressed in CHO cells
Agonist activity at rat muscarinic M4 receptor expressed in CHO cells
|
[PMID: 21930376] |
| CHO | EC50 |
>30 μM
Compound: 17, VU0364572
|
Agonist activity at rat muscarinic M5 receptor expressed in CHO cells
Agonist activity at rat muscarinic M5 receptor expressed in CHO cells
|
[PMID: 21930376] |
| CHO | EC50 |
0.11 μM
Compound: 17, VU0364572
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Agonist activity at rat muscarinic M1 receptor expressed in CHO cells
Agonist activity at rat muscarinic M1 receptor expressed in CHO cells
|
[PMID: 21930376] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1240514-87-7
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分子量 373.49
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分子式 C21H31N3O3
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SMILES
O=C(N1CCC(N2C[C@H](NC(C3=CC=CC=C3C)=O)CCC2)CC1)OCC
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Lebois EP, et al. Disease-Modifying Effects of M1 Muscarinic Acetylcholine Receptor Activation in an Alzheimer's Disease Mouse Model. ACS Chem Neurosci. 2017 Jun 21;8(6):1177-1187. [Content Brief]
[2]. Faruk MO, et al. Muscarinic signaling regulates voltage-gated potassium channel KCNQ2 phosphorylation in the nucleus accumbens via protein kinase C for aversive learning. J Neurochem. 2022 Feb;160(3):325-341. [Content Brief]
[3]. Lebois EP, et al. Development of a highly selective, orally bioavailable and CNS penetrant M1 agonist derived from the MLPCN probe ML071. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6451-5. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
VU0364572 関連分類
HY-113616 関連分類
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