ZA3-Ep10
Based on 1 Customer Validation
ZA3-Ep10 is a zwitterionic lipid used in lipid nanoparticles formulation for in vivo RNA delivery.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.93%
- CAS 番号: 2090299-48-0
- 分子式: C66H138N6O9S
- 分子量:1191.90
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保管条件:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
ZA3-Ep10 Cas9 mRNA ZNPs (4 h) shows high Cas9 mRNA level in A549 lung cancer cells[4].
ZNPs formulated with the lead ZA3-EP10, are capable of delivering different RNA cargoes including sgRNA, mCherry mRNA, and luciferase mRNA to human ovarian cancer cell line IGROV1[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2090299-48-0
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性状 Oil
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分子量 1191.90
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分子式 C66H138N6O9S
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Color White to light yellow
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SMILES
O=C(CCN(CC(CCCCCCCC)O)CCN(CCN(CC(CCCCCCCC)O)CC(CCCCCCCC)O)CCN(CC(CCCCCCCC)O)CC(CCCCCCCC)O)NCC[N+](C)(CCCS(=O)([O-])=O)C
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
DMSO : ≥ 100 mg/mL (83.90 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Cationic sulfonamide amino lipids and amphiphilic zwitterionic amino lipids. WO2017201076A1
[2]. Melamed JR, Hajj KA, Chaudhary N, et al. Lipid nanoparticle chemistry determines how nucleoside base modifications alter mRNA delivery. J Control Release. 2022;341:206-214. [Content Brief]
[3]. Melamed JR, et al. Lipid nanoparticle chemistry determines how nucleoside base modifications alter mRNA delivery. J Control Release. 2022 Jan;341:206-214. [Content Brief]
[4]. Miller JB, et al. Non-Viral CRISPR/Cas Gene Editing In Vitro and In Vivo Enabled by Synthetic Nanoparticle Co-Delivery of Cas9 mRNA and sgRNA. Angew Chem Int Ed Engl. 2017 Jan 19;56(4):1059-1063. [Content Brief]
[5]. He S, et al. Zwitterionic materials for nucleic acid delivery and therapeutic applications. J Control Release. 2024 Jan;365:919-935. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.8390 mL | 4.1950 mL | 8.3900 mL | 20.9749 mL |
| 5 mM | 0.1678 mL | 0.8390 mL | 1.6780 mL | 4.1950 mL | |
| 10 mM | 0.0839 mL | 0.4195 mL | 0.8390 mL | 2.0975 mL | |
| 15 mM | 0.0559 mL | 0.2797 mL | 0.5593 mL | 1.3983 mL | |
| 20 mM | 0.0419 mL | 0.2097 mL | 0.4195 mL | 1.0487 mL | |
| 25 mM | 0.0336 mL | 0.1678 mL | 0.3356 mL | 0.8390 mL | |
| 30 mM | 0.0280 mL | 0.1398 mL | 0.2797 mL | 0.6992 mL | |
| 40 mM | 0.0210 mL | 0.1049 mL | 0.2097 mL | 0.5244 mL | |
| 50 mM | 0.0168 mL | 0.0839 mL | 0.1678 mL | 0.4195 mL | |
| 60 mM | 0.0140 mL | 0.0699 mL | 0.1398 mL | 0.3496 mL | |
| 80 mM | 0.0105 mL | 0.0524 mL | 0.1049 mL | 0.2622 mL |
ZA3-Ep10 関連分類
HY-145794 関連分類
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