Anticancer agent 343
Based on 1 Customer Validation
Anticancer agent 343 is a heterobifunctional anticancer compound and growth inhibitor with moderate cancer cell growth inhibitory activity. Anticancer agent 343 can be used for cancer research.
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- Purity: 98.84%
- CAS No.: 3099595-74-8
- 화학식: C47H44ClN5O5S2
- 분자량:858.47
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보관:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
Anticancer agent 343 (I-16) inhibits proliferation of T-Rex 293 cells (with or without increased estrogen receptor alpha expression) with a GI50 greater than 2.5 μM[1].
Anticancer agent 343 (I-16) (0.05-0.5 μM; 6 days) inhibits proliferation of MCF7 (ATCC) cells with a GI50 between 0.05 μM and 0.5 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF7 cells (ATCC strain)
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Concentration:0.05-0.5 μM
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Incubation Time:6 days
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Result:Inhibited proliferation of MCF7 (ATCC) cells with a GI50 in the range of 0.05 μM to 0.5 μM.
Chemical Information
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CAS No. 3099595-74-8
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Appearance Solid
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분자량 858.47
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화학식 C47H44ClN5O5S2
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Color Light yellow to yellow
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SMILES
CC(SC1=C2C(C3=CC=C(C=C3)Cl)=N[C@@H](CC(NCCCCCCCOC4=CC=C(C=C4)C(C5=C(SC6=C5C=CC(O)=C6)C7=CC=C(C=C7)O)=O)=O)C8=NN=C(C)N18)=C2C
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선적
Room temperature in continental US; may vary elsewhere.
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보관
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
용액&용해도
DMSO : ≥ 100 mg/mL (116.49 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (2.91 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.5 mg/mL (2.91 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
순도&문서
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.1649 mL | 5.8243 mL | 11.6486 mL | 29.1216 mL |
| 5 mM | 0.2330 mL | 1.1649 mL | 2.3297 mL | 5.8243 mL | |
| 10 mM | 0.1165 mL | 0.5824 mL | 1.1649 mL | 2.9122 mL | |
| 15 mM | 0.0777 mL | 0.3883 mL | 0.7766 mL | 1.9414 mL | |
| 20 mM | 0.0582 mL | 0.2912 mL | 0.5824 mL | 1.4561 mL | |
| 25 mM | 0.0466 mL | 0.2330 mL | 0.4659 mL | 1.1649 mL | |
| 30 mM | 0.0388 mL | 0.1941 mL | 0.3883 mL | 0.9707 mL | |
| 40 mM | 0.0291 mL | 0.1456 mL | 0.2912 mL | 0.7280 mL | |
| 50 mM | 0.0233 mL | 0.1165 mL | 0.2330 mL | 0.5824 mL | |
| 60 mM | 0.0194 mL | 0.0971 mL | 0.1941 mL | 0.4854 mL | |
| 80 mM | 0.0146 mL | 0.0728 mL | 0.1456 mL | 0.3640 mL | |
| 100 mM | 0.0116 mL | 0.0582 mL | 0.1165 mL | 0.2912 mL |
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