AUH-6-96
AUH-6-96 is a JAK/STAT signaling inhibitor. AUH-6-96 reduces Unpaired-induced transcriptional activity in Drosophila cells and blocks tyrosine phosphorylation of STAT92E. AUH-6-96 blocks both constitutive and IL-6-induced phosphorylation of STAT3. AUH-6-96 decreases the level of tyrosine-phosphorylated JAK3. AUH-6-96 induces cancer cell Apoptosis by downregulating the expression of anti-apoptotic genes downstream of STAT3. AUH-6-96 selectively reduces the viability of cancer cells with abnormal JAK/STAT signaling pathway. AUH-6-96 is applicable to related research on Hodgkin's lymphoma, breast cancer, and prostate cancer.
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- CAS No.: 1005144-85-3
- 화학식: C28H20F6N4O5
- 분자량:606.47
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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JAK3 |
STAT3 |
AUH-6-96 (5-40 μM; 24 h) inhibits the transcriptional activity of STAT92E in cultured *Drosophila melanogaster* S2-NP cells. Treatment with 10 μM reduces the activity by more than 50%, while treatment with 40 μM for 24 h completely blocks this activity[1].
AUH-6-96 (40 μM; 24 h) almost completely inhibits Upd-induced tyrosine phosphorylation of STAT92E in transiently transfected *Drosophila melanogaster* S2-NP cells[1].
AUH-6-96 (5-40 μM; 24 h) inhibits constitutive STAT3 phosphorylation in MDA-MB-468 and DU145 cancer cells in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human cancer cell lines (Hodgkin lymphoma L540, breast cancer MDA-MB-468, prostate cancer DU145)
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Concentration:5, 10, 20, 30, 40 μM
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Incubation Time:24 h
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Result:Reduced constitutive phospho-STAT3 levels by more than 50% in L540 cells at 10 μM.
Almost completely inhibited phospho-STAT3 levels in L540 cells at 40 μM.
Caused a dramatic reduction in constitutive phospho-STAT3 levels in MDA-MB-468 and DU145 cells at 40 μM.
Left total STAT3 levels unchanged in all cell lines.
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Cell Line:Hodgkin lymphoma L540 cells
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Concentration:5, 10, 20, 30, 40 μM
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Incubation Time:24 h
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Result:Almost completely eliminated constitutive phospho-JAK3 levels, while total JAK3 levels remained unchanged.
Inhibited phospho-STAT5 levels in a dose-dependent manner, with total STAT5 levels unchanged.
Did not affect Lyn phosphorylation at 20 μM.
Reduced phospho-Lyn levels but also lowered total Lyn levels at 40 μM.
Caused no changes in phospho-ERK1/2 or total ERK1/2 levels at concentrations up to 40 μM.
Chemical Information
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CAS No. 1005144-85-3
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분자량 606.47
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화학식 C28H20F6N4O5
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SMILES
O=C1N(C2=CC=CC=C2)C(C3C1C=CC(C(C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)O)N3NC5=CC=C([N+]([O-])=O)C=C5)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AUH-6-96 Related Classifications
HY-115438 Related Classifications
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