1005144-85-3
Chemical Structure
AUH-6-96
- CAS No.: 1005144-85-3
- Formula:C28H20F6N4O5
- Molecular Weight:606.47
IUPAC Name: 2-((3,5-bis(trifluoromethyl)phenyl)(hydroxy)methyl)-1-((4-nitrophenyl)amino)-6-phenyl-1,2,4a,7a-tetrahydro-5H-pyrrolo[3,4-b]pyridine-5,7(6H)-dione
InChIKey: AJBUQKRAPCIJPQ-UHFFFAOYSA-N
SMILES: O=C1N(C2=CC=CC=C2)C(C3C1C=CC(C(C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)O)N3NC5=CC=C([N+]([O-])=O)C=C5)=O
Biological Activity: AUH-6-96 is a JAK/STAT signaling inhibitor. AUH-6-96 reduces Unpaired-induced transcriptional activity in Drosophila cells and blocks tyrosine phosphorylation of STAT92E. AUH-6-96 blocks both constitutive and IL-6-induced phosphorylation of STAT3. AUH-6-96 decreases the level of tyrosine-phosphorylated JAK3. AUH-6-96 induces cancer cell Apoptosis by downregulating the expression of anti-apoptotic genes downstream of STAT3. AUH-6-96 selectively reduces the viability of cancer cells with abnormal JAK/STAT signaling pathway. AUH-6-96 is applicable to related research on Hodgkin's lymphoma, breast cancer, and prostate cancer[1].
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AUH-6-96 | AUH-6-96 is a JAK/STAT signaling inhibitor. AUH-6-96 reduces Unpaired-induced transcriptional activity in Drosophila cells and blocks tyrosine phosphorylation of STAT92E. AUH-6-96 blocks both constitutive and IL-6-induced phosphorylation of STAT3. AUH-6-96 decreases the level of tyrosine-phosphorylated JAK3. AUH-6-96 induces cancer cell Apoptosis by downregulating the expression of anti-apoptotic genes downstream of STAT3. AUH-6-96 selectively reduces the viability of cancer cells with abnormal JAK/STAT signaling pathway. AUH-6-96 is applicable to related research on Hodgkin's lymphoma, breast cancer, and prostate cancer. | |||||||||||||||||||||
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