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Cat. No.: HY-112477

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Chk2-IN-1

(Synonyms: Hymenialdisine analogue-1)

Chk2-IN-1 (compound 1) is a potent and selective inhibitor of checkpoint kinase 2 (Chk2), with IC₅₀s of 13.5 nM and 220.4 nM for Chk2 and Chk1, respectively. Chk2-IN-1 can elicit a strong ataxia telangiectasia mutated (ATM)-dependent Chk2-mediated radioprotection effect.

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CAS No.: 724708-21-8
화학식: C₁₅H₁₃N₅O₂
분자량:295.30

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

Chk2-IN-1 Chemical Structure

CAS No.: 724708-21-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

Chk2

13.5 nM (IC₅₀)

Chk1

220.4 nM (IC₅₀)

CHKα1

All Checkpoint Kinase (Chk) Isoforms :

All Choline Kinase Isoforms :

CHKα

Cellular Effect

Cell Line	Type	Value	Description	References
CCRF-CEM	GI₅₀	1.7 μM Compound: 4	Growth inhibition of human CCRF-CEM cells up to 48 hrs by trypan blue exclusion assay Growth inhibition of human CCRF-CEM cells up to 48 hrs by trypan blue exclusion assay	[PMID: 22995819]
Jurkat	IC₅₀	3.5 μM Compound: 4	Inhibition of PMA- and PHA-stimulated IL2 production in human Jurkat T cells incubated for 30 mins prior to PMA- and PHA-stimulation by competitive enzyme immunoassay Inhibition of PMA- and PHA-stimulated IL2 production in human Jurkat T cells incubated for 30 mins prior to PMA- and PHA-stimulation by competitive enzyme immunoassay	[PMID: 22995819]
Jurkat	IC₅₀	3.5 μM Compound: 64	Antiinflammatory activity in PMA induced human Jurkat cells assessed as inhibition of IL-2 production by EIA assay Antiinflammatory activity in PMA induced human Jurkat cells assessed as inhibition of IL-2 production by EIA assay	[PMID: 36496202]
Jurkat	IC₅₀	3.55 μM Compound: 2	Inhibition of IL-2 production was determined in Jurkat cells after PMA/PHA activation by Enzyme immunoassay Inhibition of IL-2 production was determined in Jurkat cells after PMA/PHA activation by Enzyme immunoassay	[PMID: 15214798]
THP-1	IC₅₀	3.5 μM Compound: 2d	Antiinflammatory activity in human THP-1 cells assessed as inhibition of LPS-stimulated IL2 production Antiinflammatory activity in human THP-1 cells assessed as inhibition of LPS-stimulated IL2 production	[PMID: 33901899]
THP-1	IC₅₀	8.16 μM Compound: 2	Inhibition of TNF-alpha production was determined in THP-1cells after LPS activation by Enzyme immunoassay Inhibition of TNF-alpha production was determined in THP-1cells after LPS activation by Enzyme immunoassay	[PMID: 15214798]
THP-1	IC₅₀	8.2 μM Compound: 4	Inhibition of LPS-induced TNFalpha production in human THP1 cells incubated for 30 mins prior to LPS-challenge by competitive enzyme immunoassay Inhibition of LPS-induced TNFalpha production in human THP1 cells incubated for 30 mins prior to LPS-challenge by competitive enzyme immunoassay	[PMID: 22995819]
THP-1	IC₅₀	8.2 μM Compound: 2d	Antiinflammatory activity in human THP-1 cells assessed as inhibition of LPS-stimulated TNFalpha production Antiinflammatory activity in human THP-1 cells assessed as inhibition of LPS-stimulated TNFalpha production	[PMID: 33901899]
THP-1	IC₅₀	8.2 μM Compound: 64	Antiinflammatory activity in LPS induced human THP-1 cells assessed as inhibition of TNF-alpha production by EIA assay Antiinflammatory activity in LPS induced human THP-1 cells assessed as inhibition of TNF-alpha production by EIA assay	[PMID: 36496202]

Chemical Information

CAS No. 724708-21-8
분자량 295.30
화학식 C₁₅H₁₃N₅O₂
SMILES

O=C(C(N1)=C/2C3=C1C=CC=C3)NCCC2=C4N=C(N)NC\4=O
Synonyms

Hymenialdisine analogue-1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Nguyen TNT, et, al. Radioprotection by hymenialdisine-derived checkpoint kinase 2 inhibitors. ACS Chem Biol. 2012 Jan 20;7(1):172-84. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
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상품명:
CAS No.:
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Chk2-IN-1

All Checkpoint Kinase (Chk) Isoforms

All Choline Kinase Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Chk2-IN-1 Related Classifications

HY-112477 Related Classifications