724708-21-8
Chemical Structure
Chk2-IN-1
Synonym(s): Hymenialdisine analogue-1
- CAS No.: 724708-21-8
- Formula:C15H13N5O2
- Molecular Weight:295.30
IUPAC Name: (Z)-5-(2-amino-5-oxo-1,5-dihydro-4H-imidazol-4-ylidene)-3,4,5,10-tetrahydroazepino[3,4-b]indol-1(2H)-one
InChIKey: SMPPSGXPGZSJCP-FLIBITNWSA-N
SMILES: O=C(C(N1)=C/2C3=C1C=CC=C3)NCCC2=C4N=C(N)NC\4=O
Biological Activity: Chk2-IN-1 (compound 1) is a potent and selective inhibitor of checkpoint kinase 2 (Chk2), with IC50s of 13.5 nM and 220.4 nM for Chk2 and Chk1, respectively. Chk2-IN-1 can elicit a strong ataxia telangiectasia mutated (ATM)-dependent Chk2-mediated radioprotection effect[1].
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Chk2-IN-1 | Chk2-IN-1 (compound 1) is a potent and selective inhibitor of checkpoint kinase 2 (Chk2), with IC50s of 13.5 nM and 220.4 nM for Chk2 and Chk1, respectively. Chk2-IN-1 can elicit a strong ataxia telangiectasia mutated (ATM)-dependent Chk2-mediated radioprotection effect. | |||||||||||||||||||||
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Keywords
