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United States

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Cat. No.: HY-184709

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COX-2-IN-68

COX-2-IN-69 is a selective, orally active COX-2 inhibitor with an IC₅₀ of 0.82 μM. COX-2-IN-69 occupies the secondary pocket of COX-2, interacts with His90 and Arg513, and reduces the serum levels of PGE₂, IL-1β and TNF-α. COX-2-IN-69 exerts anti-inflammatory activity in a rat paw edema model. COX-2-IN-69 can be used in inflammation-related research.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₂₁H₁₉BrN₂O₃
분자량:427.29

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

COX-2-IN-68 Chemical Structure

사이즈

가격

재고

수량

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

COX-2

0.82 μM (IC₅₀)

IL-1β

All COX Isoforms :

All Interleukin Related Isoforms :

All TNF Receptor Isoforms :

In Vivo

COX-2-IN-68 (Compound 4e) (10 mg/kg; p.o.; single administration) exhibits potent in vivo anti-inflammatory activity in a rat paw edema model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague Dawley (male, 130-150 g, Carrageenan (HY-125474)-induced paw edema model)^[1]
Dosage:

10 mg/kg
Administration:

p.o.; single dose
Result:

Produced edema percentages of 17.58% at 1 h, 14.22% at 2 h, and 13.89% at 3 h post-Carrageenan injection.
Reduced serum PGE2 levels by 61.48% compared to the Carrageenan control group.
Reduced serum IL-1β levels by 62.17% compared to the carrageenan control group.
Reduced serum TNF-α levels by 58.36% compared to the carrageenan control group.
Showed moderate desquamation of gastric mucosa, inflammatory cell infiltration of the submucosa layer, and vacuolar degeneration of gastric glands, with milder gastric effects than indomethacin.

Chemical Information

분자량 427.29
화학식 C₂₁H₁₉BrN₂O₃
SMILES

CCOC1=C(O)C=CC(/C=C/C2=NNC(C(CC3=CC=C(Br)C=C3)=C2)=O)=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Elbahrawy AH, et al. Design, synthesis, biological evaluation and histopathological studies of Pyridazine and Pyrazoline derivatives as potential anti-inflammatory agents. Bioorganic chemistry. 2026 Jun 24;180:110164. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vivo
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

COX-2-IN-68

All COX Isoforms

All Interleukin Related Isoforms

All TNF Receptor Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

COX-2-IN-68 Related Classifications

HY-184709 Related Classifications