PPP2R5D - protein phosphatase 2 regulatory subunit B'delta Gene

Also Known as B56D; MRD35; B56delta

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5528

About PPP2R5D

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:42,984,570-43,012,342 (from NCBI)

This gene has 10 transcripts (splice variants), 207 orthologues, 4 paralogues and is associated with 3 phenotypes. Ubiquitous expression in testis (RPKM 23.6), brain (RPKM 18.9) and 25 other tissues.

Summary

The product of this gene belongs to the Phosphatase 2A regulatory subunit B family. Protein Phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a delta isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

PPP2R5D Products (4)

mRNA	Protein	Name
NM_001270476.2	NP_001257405.1	serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform 4
NM_006245.4	NP_006236.1	serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform 1
NM_180976.3	NP_851307.1	serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform 2
NM_180977.3	NP_851308.1	serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform 3

PPP2R5D Protein Structure

B56

0
100
200
300
400
500
602 a.a.

Protein Preferred Names	Protein Names
serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

PPP2R5D Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PPP2R5D	Q14738	PPP2R1A	Homo sapiens	P30153	Anti Tag CoIP	26496610
Intra	PPP2R5D	Q14738	PPP2R1B	Homo sapiens	P30154	Y2H	23555304
Intra	PPP2R5D	Q14738	PPP2R1B	Homo sapiens	P30154	Anti Tag CoIP	26496610
Intra	PPP2R5D	Q14738	FSD2	Homo sapiens	A1L4K1	Y2H Array	25416956
Intra	PPP2R5D	Q14738	FSD2	Homo sapiens	A1L4K1	Validated Y2H	25416956
Intra	PPP2R5D	Q14738	USHBP1	Homo sapiens	Q8N6Y0	Y2H Prey Pooling	25416956
Intra	PPP2R5D	Q14738	DYDC1	Homo sapiens	Q8WWB3	Validated Y2H	32296183
Intra	PPP2R5D	Q14738	DYDC1	Homo sapiens	Q8WWB3	Y2H Array	32296183
Intra	PPP2R5D	Q14738	DYDC1	Homo sapiens	Q8WWB3	Y2H Prey Pooling	32296183
Intra	PPP2R5D	Q14738	PPFIA1	Homo sapiens	Q13136	Y2H Array	29892012
Intra	PPP2R5D	Q14738	PPFIA1	Homo sapiens	Q13136	Y2H Pooling	16189514
Intra	PPP2R5D	Q14738	PPFIA1	Homo sapiens	Q13136	Anti Tag CoIP	26496610
Intra	PPP2R5D	Q14738	SGO1	Homo sapiens	Q5FBB7	Y2H	21666598
Intra	PPP2R5D	Q14738	SGO1	Homo sapiens	Q5FBB7	Y2H	16541025

Cross: Cross-species interaction Intra: Intraspecies interaction

PPP2R5D Antibodies

Cat. No.	상품명	신청	Reactivity
HY-P81960	PPP2R5D Antibody (YA1705)	WB, IP	Human, Mouse, Rat
HY-P81960A	PPP2R5D Antibody (YA1705)(PBS only)	WB, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Intellectual Developmental Disorder, Autosomal Dominant 35	MRD35 Intellectual Disability-Macrocephaly-Hypotonia-Behavioral Abnormalities Syndrome Autosomal Dominant Non-Syndromic Intellectual Disability 35 Mental Retardation, Autosomal Dominant 35 Autosomal Dominant Intellectual Developmental Disorder 35 Autosomal Dominant Mental Retardation 35 Mental Retardation, Autosomal Dominant, Type 35
Encephalopathy	Brain Diseases Encephalopathies Toxic Encephalopathy Toxic Brain Fever Toxic Brain Inflammation Toxic Brain Stem Inflammation Toxic Cerebral Fever Toxic Cerebrospinal Fever Toxic Cerebrospinal Inflammation Encephalopathy Nec Encephalopathy Nos Encephalopathy Disease Encephalopathy Syndrome
Macrocephaly/Autism Syndrome	Macrocephaly-Autism Syndrome Macrocephaly-Intellectual Disability-Autism Syndrome MCEPHAS
Alzheimer Disease 8	Ad8 Alzheimer'S Disease 8 Alzheimer Disease, Familial, 8 Alzheimer Disease, Familial 8 Alzheimer'S Disease 8, Late Onset
Noonan Syndrome 4	NS4 Noonan Syndrome, Type 4
Intellectual Developmental Disorder, Autosomal Dominant 13	MRD13 Mental Retardation, Autosomal Dominant 13 Mental Retardation, Autosomal Dominant 13, With Neuronal Migration Defects Autosomal Dominant Non-Syndromic Intellectual Disability 13 Autosomal Dominant Intellectual Developmental Disorder 13 Autosomal Dominant Mental Retardation 13 Mental Retardation, Autosomal Dominant, Type 13
Cornelia De Lange Syndrome	De Lange Syndrome Brachmann De Lange Syndrome Brachmann-De Lange Syndrome Cdls Bdls Typus Degenerativus Amstelodamensis
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Lissencephaly	Pachygyria Broad Gyri Of Cerebrum Large Gyri Of Cerebrum Macrogyria
Epilepsy, Myoclonic Juvenile	Juvenile Myoclonic Epilepsy Janz Syndrome Jme Myoclonic Epilepsy, Juvenile, Susceptibility To, 1 EJM Myoclonic Epilepsy, Juvenile Petit Mal, Impulsive Myoclonic Epilepsy, Juvenile 1 Myoclonic Epilepsy, Juvenile, 1 Adolescent Myoclonic Epilepsy Juvenile Myoclonus Epilepsy Juvenile Myoclonic Epilepsy 1 EJM1 Petit Mal Impulsive Susceptibility To Juvenile Myoclonic Epilepsy 1 Myoclonic Epilepsy Juvenile Epilepsy, Myoclonic, Juvenile Myoclonic Epilepsy Of Janz Jme - [Juvenile Myoclonic Epilepsy]
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-RS11021	PPP2R5D Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PPP2R5D	RGD	RGD:1306666
Felis catus	PPP2R5D	VGNC	VGNC:69018
Macaca mulatta	PPP2R5D	VGNC	VGNC:76380
Mus musculus	PPP2R5D	MGD	MGI:2388481
Bos taurus	PPP2R5D	VGNC	VGNC:33263
Canis familiaris	PPP2R5D	VGNC	VGNC:44916
Others	PPP2R5D	NCBI