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Cat. No.: HY-124305

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ML395

1 Cited Publications

고객리뷰

Based on 1 publication(s) in Google Scholar

ML395 is a potent and selective allosteric inhibitor of phospholipase D2 with antiviral activity. The cellular PLD1 IC50 value of ML395 exceeds 30,000 nM, while its cellular PLD2 IC50 value is 360 nM. ML395 shows excellent pharmacokinetic characteristics in vitro and physiochemical properties superior to other reported phospholipase inhibitors. ML395 shows interesting antiviral activity in cell-based assays against multiple influenza virus strains (H1, H3, H5, and H7).

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CAS No.: 1638957-17-1
화학식: C₂₆H₂₉N₅O₂
분자량:443.54

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

ML395 Chemical Structure

CAS No.: 1638957-17-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

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Chemical Information

CAS No. 1638957-17-1
분자량 443.54
화학식 C₂₆H₂₉N₅O₂
SMILES

O=C(C1=CC=C2C=CC=CC2=C1)NCCN(CC3)CCC3(N(CC4=CC=CN=C4)CN5)C5=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Am J Orthod Dentofacial Orthop

Force threshold-dependent modulation of root resorption via the Nrf2/Keap1/p62 antioxidant pathway during orthodontic tooth movement. [Abstract]

2025 Dec 4:S0889-5406(25)00481-0. PMID: 41342829

순도&문서

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Discovery of a highly selective PLD2 inhibitor (ML395): a new probe with improved physiochemical properties and broad-spectrum antiviral activity against influenza strains

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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Chemical Information
Publications (1)
순도&문서
References

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ML395

Publications Citing Use of MedChemExpress (MCE) ML395

All Endogenous Metabolite Isoforms