Pichromene
Based on 1 Customer Validation
Pichromene (S14161) is an anticancer agent and weak PI3K inhibitor. Pichromene can effectively inhibit tumor growth in leukemia mouse models and can be used in cancer research.
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- Purity: 98.0%
- CAS No.: 883046-50-2
- 화학식: C17H14FNO4
- 분자량:315.30
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보관:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| B16 | GI50 |
23.28 μM
Compound: 2, S14161
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Cytotoxicity against mouse B16 cells after 24 to 72 hrs by SRB assay
Cytotoxicity against mouse B16 cells after 24 to 72 hrs by SRB assay
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[PMID: 23601711] |
| K562 | GI50 |
1.24 μM
Compound: 2, S14161
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Cytotoxicity against human K562 cells after 24 to 72 hrs by SRB assay
Cytotoxicity against human K562 cells after 24 to 72 hrs by SRB assay
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[PMID: 23601711] |
| LP-1 | GI50 |
0.57 μM
Compound: 2, S14161
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Cytotoxicity against human LP-1 cells after 24 to 72 hrs by SRB assay
Cytotoxicity against human LP-1 cells after 24 to 72 hrs by SRB assay
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[PMID: 23601711] |
| MDA-MB-231 | GI50 |
8.53 μM
Compound: 2, S14161
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Cytotoxicity against human MDA-MB-231 cells after 24 to 72 hrs by SRB assay
Cytotoxicity against human MDA-MB-231 cells after 24 to 72 hrs by SRB assay
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[PMID: 23601711] |
| Platelet | IC50 |
3.79 μM
Compound: S14161
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Inhibition of collagen-induced platelet aggregation in human platelet rich plasma preincubated for 10 mins followed by collagen addition by aggregometric method
Inhibition of collagen-induced platelet aggregation in human platelet rich plasma preincubated for 10 mins followed by collagen addition by aggregometric method
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[PMID: 27996269] |
| U-87MG ATCC | GI50 |
18.72 μM
Compound: 2, S14161
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Cytotoxicity against human U87 cells after 24 to 72 hrs by SRB assay
Cytotoxicity against human U87 cells after 24 to 72 hrs by SRB assay
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[PMID: 23601711] |
Chemical Information
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CAS No. 883046-50-2
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Appearance Solid
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분자량 315.30
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화학식 C17H14FNO4
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Color Off-white to light yellow
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SMILES
O=[N+](C1=CC2=CC=CC(OCC)=C2OC1C3=CC=C(F)C=C3)[O-]
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Synonyms
S14161
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
순도&문서
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Data Sheet (270 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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Handling Instructions (2659 KB)
References
[1]. Mao X, et al. A small-molecule inhibitor of D-cyclin transactivation displays preclinical efficacy in myeloma and leukemia via phosphoinositide 3-kinase pathway. Blood. 2011 Feb 10;117(6):1986-97. [Content Brief]
[2]. Fouqué A, et al. A Novel Covalent mTOR Inhibitor, DHM25, Shows in Vivo Antitumor Activity against Triple-Negative Breast Cancer Cells. J Med Chem. 2015 Aug 27;58(16):6559-73. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pichromene Related Classifications
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