(R)-Exatecan Intermediate 1
Based on 1 Customer Validation
(R)-Exatecan Intermediate 1 is a key intermediate in the synthesis of Camptothecin (HY-16560) derivatives, and can be used to prepare Exatecan mesylate (DX8951f) (HY-13631A). (R)-Exatecan Intermediate 1 enables the synthesis of Exatecan, which exhibits low sensitivity to multidrug resistance and has great value in anti-tumor research.
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- CAS No.: 110351-91-2
- 화학식: C13H13NO5
- 분자량:263.25
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보관:
4°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
All Topoisomerase Isoforms
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Biological Activity
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Camptothecins |
(R)-Exatecan Intermediate 1 undergoes rearrangement to form intermediate B with yields of 60-79% under specified temperature and time conditions[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 110351-91-2
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Appearance Solid
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분자량 263.25
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화학식 C13H13NO5
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Color Light yellow to light brown
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SMILES
O=C1[C@@](O)(CC)C(C=C23)=C(CO1)C(N3CCC2=O)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
용액&용해도
DMSO : 100 mg/mL (379.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (278 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[2]. Weng W, et al. Antibody-Exatecan Conjugates with a Novel Self-immolative Moiety Overcome Resistance in Colon and Lung Cancer. Cancer Discov. 2023;13(4):950-973. [Content Brief]
[3]. Conilh L, et al. Exatecan Antibody Drug Conjugates Based on a Hydrophilic Polysarcosine Drug-Linker Platform. Pharmaceuticals (Basel). 2021;14(3):247. Published 2021 Mar 9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.7987 mL | 18.9934 mL | 37.9867 mL | 94.9668 mL |
| 5 mM | 0.7597 mL | 3.7987 mL | 7.5973 mL | 18.9934 mL | |
| 10 mM | 0.3799 mL | 1.8993 mL | 3.7987 mL | 9.4967 mL | |
| 15 mM | 0.2532 mL | 1.2662 mL | 2.5324 mL | 6.3311 mL | |
| 20 mM | 0.1899 mL | 0.9497 mL | 1.8993 mL | 4.7483 mL | |
| 25 mM | 0.1519 mL | 0.7597 mL | 1.5195 mL | 3.7987 mL | |
| 30 mM | 0.1266 mL | 0.6331 mL | 1.2662 mL | 3.1656 mL | |
| 40 mM | 0.0950 mL | 0.4748 mL | 0.9497 mL | 2.3742 mL | |
| 50 mM | 0.0760 mL | 0.3799 mL | 0.7597 mL | 1.8993 mL | |
| 60 mM | 0.0633 mL | 0.3166 mL | 0.6331 mL | 1.5828 mL | |
| 80 mM | 0.0475 mL | 0.2374 mL | 0.4748 mL | 1.1871 mL | |
| 100 mM | 0.0380 mL | 0.1899 mL | 0.3799 mL | 0.9497 mL |
(R)-Exatecan Intermediate 1 Related Classifications
HY-42487B Related Classifications
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