2. Apoptosis Cell Cycle/DNA Damage
  3. Apoptosis DNA/RNA Synthesis
  4. L-Asparaginase

L-Asparaginase  (Synonyms: L-​ASNase)

Cat. No.: HY-P1923 Purity: 99.77%
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L-Asparaginase (L-ASNase) is a deamidating enzyme that catalyses the hydrolysis of L-asparagine and L-glutamine, and can be used for the research of acute lymphoblastic leukemia. L-Asparaginase depletes L-asparagine from plasma resulting in inhibition of RNA and DNA synthesis with the subsequent blastic cell apoptosis.

For research use only. We do not sell to patients.

L-Asparaginase Chemical Structure

L-Asparaginase Chemical Structure

CAS No. : 9015-68-3

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1 mg USD 70 In-stock
5 mg USD 125 In-stock
10 mg USD 210 In-stock
25 mg USD 330 In-stock
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This product is a controlled substance and not for sale in your territory.

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Based on 6 publication(s) in Google Scholar

L-Asparaginase Related Antibodies

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Description

L-Asparaginase (L-ASNase) is a deamidating enzyme that catalyses the hydrolysis of L-asparagine and L-glutamine, and can be used for the research of acute lymphoblastic leukemia. L-Asparaginase depletes L-asparagine from plasma resulting in inhibition of RNA and DNA synthesis with the subsequent blastic cell apoptosis[1].

In Vitro

L-Asparaginase has a cytotoxic effect on AML blasts and LSC subpopulations[1].
L-Asparaginase is effective on both CD34+CD38+ and CD34+CD38+ LSC fractions, MSC and monocytes/macrophages partially counteracted the effect[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

L-Asparaginase Related Antibodies
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[L-Asparaginase]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (Need ultrasonic)

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 25 mg/mL (Infinity mM); Clear solution; Need ultrasonic

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Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.91%

COA (229 KB) RP-HPLC (165 KB)

Handling Instructions (2659 KB)
References
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L-Asparaginase Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Asparaginase9015-68-3L-​ASNaseApoptosisDNA/RNA Synthesisdeamidating enzymeL-asparagineacute lymphoblastic leukemiaRNA synthesisDNA synthesisapoptosiscancerInhibitorinhibitorinhibit

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