L-Lysine α-oxidase

Name: L-Lysine α-oxidase
Brand: MedChemExpress
SKU: HY-P2965
Rating: 4.5 (0 reviews)

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L-Lysine α-oxidase is a potent anticancer agent. L-Lysine α-oxidase also a L-amino acid oxidase, deaminates L-lysine with the yield of H2O2, ammonia, and α-keto-ε-aminocaproate. L-Lysine α-oxidase shows cytotoxicity and anticancer activity.

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L-Lysine α-oxidase Estructura química

No. CAS : 70132-14-8

Tamaño	Precio	Stock	Cantidad
25 U		En stock	Estimated Time of Arrival: December 31

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Descripciòn

In Vitro

L-Lysine α-oxidase shows cytotoxicity for HT29, LS174T, MCF7, SKOV3, PC3, K562 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

L-Lysine α-oxidase (150 U/kg on day 2 and 75 U/kg on days 4, 6, 8, and 10; i.p.) shows anticancer activity in human tumor models^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	6-9 weeks, Female Balb/c nude mice (SKBR3, HCT116, Bro, SKOV3, Alex, T47D, LS174T tumor models)^[2]
Dosage:	150 U/kg on day 2 and 75 U/kg on days 4, 6, 8, and 10
Administration:	I.p.; 10 U/ml saline solution
Result:	Caused inhibition of tumor growth with maximal T/C of 49, 12, 51, 35, 54,36, 37% for SKBR3, HCT116, Bro, SKOV3, Alex, T47D, LS174T tumor models, respectively.

No. CAS

70132-14-8

Appearance

Solid

Color

Off-white to light yellow

SMILES

[L-Lysine alpha-oxidase]

EC Number

1.4.3.14

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

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Ficha de datos (268 KB) SDS (251 KB)

COA (243 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Lukasheva EV, et al. L-Lysine α-Oxidase: Enzyme with Anticancer Properties. Pharmaceuticals (Basel). 2021 Oct 22;14(11):1070. [Content Brief]

[2]. Pokrovsky VS, et al. Enzymatic properties and anticancer activity of L-lysine α-oxidase from Trichoderma cf. aureoviride Rifai BKMF-4268D. Anticancer Drugs. 2013 Sep;24(8):846-51. [Content Brief]