1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
    Dopamine Receptor
  3. Lurasidone-d8

Lurasidone-d8 (Synonyms: SM-13496-d8)

Cat. No.: HY-B0032AS
Handling Instructions

Lurasidone-d8 is deuterium labeled Lurasidone. Lurasidone (SM-13496) is an antagonist of both dopamine D2 and 5-HT7 with IC50s of 1.68 and 0.495 nM, respectively. Lurasidone (SM-13496) is also a partial agonist of 5-HT1A receptor with an IC50 of 6.75 nM.

For research use only. We do not sell to patients.

Lurasidone-d8 Chemical Structure

Lurasidone-d8 Chemical Structure

CAS No. : 1132654-54-6

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Description

Lurasidone-d8 is deuterium labeled Lurasidone. Lurasidone (SM-13496) is an antagonist of both dopamine D2 and 5-HT7 with IC50s of 1.68 and 0.495 nM, respectively. Lurasidone (SM-13496) is also a partial agonist of 5-HT1A receptor with an IC50 of 6.75 nM.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

500.73

Formula

C28H28D8N4O2S

CAS No.
SMILES

O=C1[[email protected]@]2([H])[[email protected]](C(N1C[[email protected]]3[[email protected]@H](CCCC3)CN4C([2H])([2H])C([2H])([2H])N(C5=NSC6=CC=CC=C56)C([2H])([2H])C4([2H])[2H])=O)([H])[[email protected]]7C[[email protected]@H]2CC7

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Lurasidone-d8
Cat. No.:
HY-B0032AS
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