Lyxose 

Lyxose is a pentose carbohydrate that serves both as a precursor for synthesizing UDP-galactopyranose mutase inhibitors in tuberculosis research and as an inhibitor of hSGLT5-mediated mannose uptake. The content of Lyxose in the cecum of mice fed a Western-style diet decreases^[1][2][3].

D-lyxose (100 mM; 30 min) acts as a low-affinity competitive inhibitor of hSGLT5-mediated mannose transport in T-Rex HEK-293 cells, with 100 mM inhibiting 50% of uptake and an estimated K_i of ≥100 mM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

150.13

C₅H₁₀O₅

65-42-9

OC[C@@H](O)[C@H](O)[C@H](O)C=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Ghezzi C, et al. Fingerprints of hSGLT5 sugar and cation selectivity. Am J Physiol Cell Physiol. 2014;306(9):C864-C870.  [Content Brief]

  [2]. Jena PK, et al. Intestinal Microbiota Remodeling Protects Mice from Western Diet-Induced Brain Inflammation and Cognitive Decline. Cells. 2022;11(3):504. Published 2022 Feb 1.  [Content Brief]

  [3]. Pan W, et al. Synthesis of acyclic galactitol-and lyxitol-aminophosphonates as inhibitors of UDP-galactopyranose mutase[J]. Tetrahedron letters, 2007, 48(25): 4353-4356.