2. Academic Validation
  3. Antitumor agents 201. Cytotoxicity of harmine and beta-carboline analogs

Antitumor agents 201. Cytotoxicity of harmine and beta-carboline analogs

  • Bioorg Med Chem Lett. 1999 Dec 6;9(23):3319-24. doi: 10.1016/s0960-894x(99)00598-3.
J Ishida 1,  H K Wang,  K F Bastow,  C Q Hu,  K H Lee
Affiliations

Affiliation

  • 1 Natural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill 27599-7360, USA.
PMID: 10612592 DOI: 10.1016/s0960-894x(99)00598-3
Abstract

Twenty-six beta-carbolines were evaluated for in vitro cytotoxicity in a human tumor cell line panel. Harmine (3) showed significant activity against several cell lines including three drug-resistant KB sublines with various resistance mechanisms. Alpha-(4-nitrobenzylidine) harmine (16) had a broad cytotoxicity spectrum (ED50 values from 0.3-1.2 microg/mL against 1A9, KB, SaOS-2, A549, SK-MEL-2, U-87-MG, and MCF-7 cells).

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