2. Academic Validation
  3. ILDR2 Is a Novel B7-like Protein That Negatively Regulates T Cell Responses

ILDR2 Is a Novel B7-like Protein That Negatively Regulates T Cell Responses

  • J Immunol. 2018 Mar 15;200(6):2025-2037. doi: 10.4049/jimmunol.1700325.
Iris Hecht 1,  Amir Toporik 2,  Joseph R Podojil 3 4,  Ilan Vaknin 2,  Gady Cojocaru 2,  Anat Oren 2,  Elizabeta Aizman 2,  Spencer C Liang 5,  Ling Leung 5,  Yosef Dicken 2,  Amit Novik 2,  Nadav Marbach-Bar 2,  Aziza Elmesmari 6,  Clare Tange 6,  Ashley Gilmour 6,  Donna McIntyre 6,  Mariola Kurowska-Stolarska 6,  Kay McNamee 7,  Judith Leitner 8,  Shirley Greenwald 2,  Liat Dassa 2,  Zurit Levine 2,  Peter Steinberger 8,  Richard O Williams 7,  Stephen D Miller 3 4,  Iain B McInnes 6,  Eyal Neria 2,  Galit Rotman 2
Affiliations

Affiliations

  • 1 Compugen Ltd., Holon 5885849, Israel; [email protected].
  • 2 Compugen Ltd., Holon 5885849, Israel.
  • 3 Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.
  • 4 Interdepartmental Immunobiology Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.
  • 5 Compugen USA Inc., South San Francisco, CA 94080.
  • 6 Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow G12 8TA, United Kingdom.
  • 7 Kennedy Institute, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford OX3 7FY, United Kingdom; and.
  • 8 Division of Immune Receptors and T Cell Activation, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, 1090 Vienna, Austria.
PMID: 29431694 DOI: 10.4049/jimmunol.1700325
Abstract

The B7-like protein family members play critical immunomodulatory roles and constitute attractive targets for the development of novel therapies for human diseases. We identified Ig-like domain-containing receptor (ILDR)2 as a novel B7-like protein with robust T cell inhibitory activity, expressed in immune cells and in immune-privileged and inflamed tissues. A fusion protein, consisting of ILDR2 extracellular domain with an Fc fragment, that binds to a putative counterpart on activated T cells showed a beneficial effect in the collagen-induced arthritis model and abrogated the production of proinflammatory cytokines and chemokines in autologous synovial-like cocultures of macrophages and cytokine-stimulated T cells. Collectively, these findings point to ILDR2 as a novel negative regulator for T cells, with potential roles in the development of immune-related diseases, including autoimmunity and Cancer.

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