A new phenol derivative isolated from mangrove-derived fungus Eupenicillium sp. HJ002

  • Nat Prod Res. 2021 Nov;35(21):4051-4057. doi: 10.1080/14786419.2020.1712388.
Rong-Qing Mei  1  2 ,  Xu-Hua Nong  1  2 ,  Bin Wang  1  2 ,  Xue-Ping Sun  3 ,  Guo-Lei Huang  1  2 ,  You-Ping Luo  1  2 ,  Cai-Juan Zheng  1  2 ,  Guang-Ying Chen  1  2
Affiliations
  • 1. Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, China.
  • 2. Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, People's Republic of China.
  • 3. Guangxi Engineering Technology Research Center of Advantage Chinese Patent Drug and Ethnic Drug Development, College of pharmacy, Guangxi University of Chinese Medicine, Nanning, People's Republic of China.
PMID: 31960725 DOI: 10.1080/14786419.2020.1712388
Abstract

A new phenol derivative, 3-chloro-5-hydroxy-4-methoxyphenylacetic acid methyl ester (1), along with five known compounds methyl 4-hydroxyphenylacetate (2), cytosporone B (3), (R)-striatisporolide A (4), (R)-butanedioic acid (5) and ergosterol (6) were isolated from the mangrove-derived fungus Eupenicillium sp. HJ002. Their structures were established by spectroscopic methods, GIAO based 13C NMR chemical shift calculations and comparison with the data of literature. Compounds 1-5 were isolated from Xylocarpus granatum Koening-derived fungus for the first time.

Keywords
Eupenicillium sp; GIAO calculations; Xylocarpus granatum Koenig.