1. Cell Cycle/DNA Damage
  2. Antifolate
    DNA/RNA Synthesis
  3. Methotrexate α-tert-butyl ester

Methotrexate α-tert-butyl ester 

Cat. No.: HY-133887
Handling Instructions

Methotrexate α-tert-butyl ester, capped by OtBu, significantly reduces tumor growth in HT1080 tumor bearing mice. Methotrexate is an antimetabolite and antifolate agent and is also an immunosuppressant and antineoplastic agent.

For research use only. We do not sell to patients.

Methotrexate α-tert-butyl ester Chemical Structure

Methotrexate α-tert-butyl ester Chemical Structure

CAS No. : 79640-70-3

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Description

Methotrexate α-tert-butyl ester, capped by OtBu, significantly reduces tumor growth in HT1080 tumor bearing mice. Methotrexate is an antimetabolite and antifolate agent and is also an immunosuppressant and antineoplastic agent[1][2][3][4].

In Vitro

OtBu-MTX-PVG is less HT1080 than MTX-PVG against HT1080 cells. It shows that protection of the α-carboxyl group of MTX results in reduced in vitro activity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Lys-MTXcleavable- (OtBu) significantly reduces tumor growth in HT1080 tumor bearing mice[1].
The protection of the α-carboxyl group of methotrexate may be used to improve the circulatory half-life and reduce the liver accumulation of similar MTX-conjugated dendrimers, while still retaining antitumor activity in vivo[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female, Balb/c nu/nu, 6 weeks (bearing HT1080 cells)[1]
Dosage: 30 mg/kg
Administration: Once per week for 2 weeks
Result: Showed a significant (63%) reduction in tumor size on day 12.
Molecular Weight

510.55

Formula

C₂₄H₃₀N₈O₅

CAS No.

79640-70-3

SMILES

O=C(O)CC[[email protected]](NC(C1=CC=C(N(CC2=NC3=C(N)N=C(N)N=C3N=C2)C)C=C1)=O)C(OC(C)(C)C)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Methotrexate α-tert-butyl esterAntifolateDNA/RNA SynthesisOtButumorgrowthHT1080cellscirculatoryhalf-lifeInhibitorinhibitorinhibit

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Methotrexate α-tert-butyl ester
Cat. No.:
HY-133887
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