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Cat. No.: HY-180706

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N2-Succinyl-L-ornithine

N2-Succinyl-L-ornithine is a metabolic intermediate and also a substrate of N²-acetylornithine 5-aminotransferase (EC 2.6.1.11). N2-Succinyl-L-ornithine acts as a precursor of Pyruvic acid (HY-Y0781) and supports the biosynthesis of α-solanine (HY-N6602) via the MEP/DOXP pathway. N2-Succinyl-L-ornithine is applicable to research related to IgA vasculitis and intestinal pathogen infections.

For research use only. We do not sell to patients.

CAS No.: 99590-80-4
Formula: C₉H₁₆N₂O₅
Molecular Weight:232.23

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

N2-Succinyl-L-ornithine Chemical Structure

CAS No.: 99590-80-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

In Vitro

N2-Succinyl-L-ornithine (1.4 mM) is efficiently transaminated by purified N²-acetylornithine 5-aminotransferase from Pseudomonas aeruginosa with an apparent K_m of 1.4 mM, supporting its role in arginine catabolism^[1].
N2-Succinyl-L-ornithine (5 mM) is converted to N-succinylglutamate 5-semialdehyde via transamination by AcOAT, and crude extracts of Pseudomonas aeruginosa contain N-succinylglutamate 5-semialdehyde dehydrogenase that acts on this product to generate N-succinylglutamate^[1].
N2-Succinyl-L-ornithine accumulates in resting Pseudomonas aeruginosa PAO1 cells treated with 10 mM Aminooxyacetate (Aminoxyacetic acid) (HY-107994A) from [U-¹⁴C]-arginine, confirming it as an intermediate in the succinyltransferase arginine catabolic pathway^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 99590-80-4
Molecular Weight 232.23
Formula C₉H₁₆N₂O₅
SMILES

NCCC[C@@H](C(O)=O)NC(CCC(O)=O)=O
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Endogenous metabolite
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jann A, et al. N-Succinylated intermediates in an arginine catabolic pathway of Pseudomonas aeruginosa. Proceedings of the National Academy of Sciences of the United States of America. 1986 Jul;83(13):4937-41.

[2]. Demir S, et al. Predictive biomarkers of IgA vasculitis with nephritis by metabolomic analysis. Seminars in arthritis and rheumatism. 2020 Dec;50(6):1238-1244.

[3]. Xing SC, et al. The Combination of Lead and Bacillus coagulans R11 Increased the Concentration of Alpha-Solanine in the Cecum of Laying Hens and the Pathogens Abundance Decreased. Front Microbiol. 2020 Oct 21;11:585197.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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