Aminoxyacetic acid
Based on 25 publication(s) in Google Scholar
Aminooxyacetic acid (Carboxymethoxylamine) is a malate-aspartate shuttle (MAS) inhibitor. Aminooxyacetic acid also inhibits the GABA degradating enzyme GABA-T.
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- Pureté : 95.0%
- CAS No.: 645-88-5
- Formule: C2H5NO3
- Masse moléculaire:91.07
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Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Aminoxyacetic acid
More- Signal Transduct Target Ther. 2023 Feb 15;8(1):65. [Abstract]
- Nat Metab. 2022 Feb;4(2):239-253. [Abstract]
- Cancer Res. 2022 Sep 16;82(18):3223-3235. [Abstract]
- Redox Biol. 2024 May:71:103112. [Abstract]
- Theranostics. 2021 Mar 24;11(12):5650-5674. [Abstract]
- Sci Adv. 2025 Aug 29;11(35):eadu6271. [Abstract]
- Sci Adv. 2025 Aug 15;11(33):eadw9241. [Abstract]
- Research (Wash D C). 2025 May 23:8:0703. [Abstract]
- Phytomedicine. 2025 Nov 25:148:157492. [Abstract]
- Cell Death Discov. 2025 Oct 6;11(1):430. [Abstract]
- Phytother Res. 2026 May;40(5):2569-2587. [Abstract]
- ACS Appl Mater Interfaces. 2025 Dec 24;17(51):69180-69195. [Abstract]
- Stem Cell Res Ther. 2025 Oct 31;16(1):603. [Abstract]
- CNS Neurosci Ther. 2023 Mar;29(3):941-956. [Abstract]
- Cell Mol Life Sci. 2024 May 3;81(1):204. [Abstract]
- Mol Nutr Food Res. 2023 Nov;67(22):e2300112. [Abstract]
- ASN Neuro. 2021 Jan-Dec:13:17590914211043087. [Abstract]
- FASEB J. 2026 May 31;40(10):e71888. [Abstract]
- J Virol. 2025 Nov 25;99(11):e0098525. [Abstract]
- Viruses. 2024 Sep 29;16(10):1540. [Abstract]
- Am J Transl Res. 2018 Dec 15;10(12):4247-4257. [Abstract]
- Res Sq. 2026 Mar 5.
- bioRxiv. 2025 July 11.
- Biomed Pharmacother. 2023 Nov:167:115605. [Abstract]
- Comput Biol Med. 2023 Oct:165:107415. [Abstract]
Customer Validation & Images
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Cell Migration/Invasion Assay
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In Vivo Efficacy Study
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WB
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Cell Proliferation/Viability Assay
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Cell Proliferation/Viability Assay
Activité biologique
Description
IC50 & Target
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HT-29 | IC50 |
140 μM
Compound: AOAA
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Antiproliferative activity against human HT-29 cells assessed as decrease in cell viability after 24 hrs by CCK8 assay
Antiproliferative activity against human HT-29 cells assessed as decrease in cell viability after 24 hrs by CCK8 assay
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[PMID: 30108705] |
| HT-29 | IC50 |
159.2 μM
Compound: AOAA
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Antiproliferative activity against human HT-29 cells after 24 hrs by CCK8 assay
Antiproliferative activity against human HT-29 cells after 24 hrs by CCK8 assay
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[PMID: 30108905] |
| HT-29 | IC50 |
286.7 μM
Compound: AOAA
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Antiproliferative activity against human HT-29 cells harboring CBS SiRNA after 24 hrs by CCK8 assay
Antiproliferative activity against human HT-29 cells harboring CBS SiRNA after 24 hrs by CCK8 assay
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[PMID: 30108905] |
In Vitro
Aminooxyacetic acid hemihydrochloride (AOAA) dose-dependently decreases the survival of C6 glioma cells. Aminooxyacetic acid hemihydrochloride treatment produces a significant increase in the percentage of the cells arrested in the stage of G0/G1, as well as a significant decrease in the percentage of the cells at S phase and G2/M phase. Aminooxyacetic acid hemihydrochloride treatment leads to an obvious decrease in the number of the cells in the phase of cell division. Aminooxyacetic acid hemihydrochloride significantly increases the percentage of the cells in both early-stage apoptosis and necrosis. Treatment of the cells with 1 mM or 5 mM Aminooxyacetic acid hemihydrochloride leads to decreased levels of aging of the cells[1]. Glutamine-dependent cell lines show greater inhibition of cell growth by Aminooxyacetic acid hemihydrochloride (AOA) compare with cells that are less glutamine dependent[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 645-88-5
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Appearance Solid
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Masse moléculaire 91.07
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Formule C2H5NO3
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Color White to off-white
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SMILES
O=C(O)CON
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Synonyms
Carboxymethoxylamine; Aminooxyacetate
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (25)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
2023 Feb 15;8(1):65. PMID: 36788227
Aminoxyacetic acid purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2023 Feb 15;8(1):65. [Abstract]
Aminooxyacetic acid hemihydrochloride (AOA) (20 μM; 48 h) decreased the migration and invasion of HCC cells expressing p5372P variant.
Aminoxyacetic acid purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2023 Feb 15;8(1):65. [Abstract]
A Parental or PSAT1 knockout PLC/PRF/5 cells were tail intravenously injected into BALB/c nude mice and the mice were treated with vehicle or Aminooxyacetic acid hemihydrochloride (AOA) (10 mg/kg; i.p.; once daily for 14 d). Aminooxyacetic acid hemihydrochloride (AOA) treatment significantly inhibited the lung metastasis of cancer cells expressing the p5372P variant in vivo.
Aminoxyacetic acid purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2023 Feb 15;8(1):65. [Abstract]
The interaction between PSAT1 and p53 was diminished by Aminooxyacetic acid hemihydrochloride (AOA) (10-20 μM) treatment while the protein level of PSAT1 was not significantly changed.
Aminoxyacetic acid purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2023 Feb 15;8(1):65. [Abstract]
Cell viability of Hep3B cells transfected with vector, p53-72P, and p53-72R plasmids was assessed. Cells were treated with regorafenib alone or Aminooxyacetic acid hemihydrochloride (AOA) (10 μM) plus regorafenib at indicated concentrations. Aminooxyacetic acid hemihydrochloride (AOA) sensitized tumor cells containing vector and p53-72P to regorafenib, while exhibiting no obvious synergistic function with regorafenib in cells containing p53-72R.
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Nat Metab
2022 Feb;4(2):239-253. PMID: 35145325
Aminoxyacetic acid purchased from MedChemExpress. Usage Cited in: Nat Metab. 2022 Feb;4(2):239-253. [Abstract]
Aminooxyacetic acid hemihydrochloride (GOT1) (1 mM; 2 d). Cell proliferation of H460 cells was quantified after treatment with inhibitors against the indicated enzymes.
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Cancer Res
GOT2 Silencing Promotes Reprogramming of Glutamine Metabolism and Sensitizes Hepatocellular Carcinoma to Glutaminase Inhibitors. [Abstract]2022 Sep 16;82(18):3223-3235. PMID: 35895805 -
Redox Biol
Enteric coronavirus PDCoV evokes a non-Warburg effect by hijacking pyruvic acid as a metabolic hub. [Abstract]2024 May:71:103112. PMID: 38461791 -
Theranostics
Endogenous glutamate determines ferroptosis sensitivity via ADCY10-dependent YAP suppression in lung adenocarcinoma. [Abstract]2021 Mar 24;11(12):5650-5674. PMID: 33897873 -
Sci Adv
Glutamate utilization fuels rapid production of mitochondrial ROS in dendritic cells and drives systemic inflammation during tularemia. [Abstract]2025 Aug 29;11(35):eadu6271. PMID: 40880474 -
Sci Adv
The small-molecule pifithrin-α deactivates ETR1 to repress shade avoidance in Arabidopsis. [Abstract]2025 Aug 15;11(33):eadw9241. PMID: 40802772 -
Research (Wash D C)
Targeting the Exonic Circular OGT RNA/O-GlcNAc Transferase/Forkhead Box C1 Axis Inhibits Asparagine- and Alanine-Mediated Ferroptosis Repression in Neuroblastoma Progression. [Abstract]2025 May 23:8:0703. PMID: 40416363 -
Phytomedicine
Salvianolic acid A targets glutamic-oxaloacetic transaminase 2 to ameliorate doxorubicin-induced myocardial oxidative injury by activating malate-aspartate NADH shuttle. [Abstract]2025 Nov 25:148:157492. PMID: 41192254 -
Cell Death Discov
Metabolic interplay between exogenous cystine and glutamine dependence in triple-negative breast cancer. [Abstract]2025 Oct 6;11(1):430. PMID: 41053011 -
Phytother Res
Targeting FOXM1/Cystathionine-β-Synthase Axis by Brusatol Inhibits Lung Cancer Malignant Progression. [Abstract]2026 May;40(5):2569-2587. PMID: 41719094 -
ACS Appl Mater Interfaces
Mitochondrial-Targeting Drug-Loaded Nanoparticles Reprogram Macrophage Metabolism via ROS/NO Co-elimination for Diabetic Wound Healing. [Abstract]2025 Dec 24;17(51):69180-69195. PMID: 41383171 -
Stem Cell Res Ther
The CBS/H2S axis regulates intestinal stem cell homeostasis and radiation-induced intestinal damage. [Abstract]2025 Oct 31;16(1):603. PMID: 41174798 -
CNS Neurosci Ther
Alpha-Asarone modulates kynurenine disposal in muscle and mediates resilience to stress-induced depression via PGC-1α induction. [Abstract]2023 Mar;29(3):941-956. PMID: 36575869 -
Cell Mol Life Sci
2024 May 3;81(1):204. PMID: 38700532 -
Mol Nutr Food Res
Agaricus blazei Murrill Polysaccharide Attenuates Periodontitis via H2 S/NRF2 Axis-Boosted Appropriate Level of Autophagy in PDLCs. [Abstract]2023 Nov;67(22):e2300112. PMID: 37775336 -
ASN Neuro
Astrocytic Hydrogen Sulfide Regulates Supraoptic Cellular Activity in the Adaptive Response of Lactating Rats to Chronic Social Stress. [Abstract]2021 Jan-Dec:13:17590914211043087. PMID: 34579557 -
FASEB J
Maternal LDHB Safeguards Redox Balance and Developmental Competence During Preimplantation Embryo Cleavage. [Abstract]2026 May 31;40(10):e71888. PMID: 42117986 -
J Virol
African swine fever virus hijacks host pyrimidine metabolism to promote viral replication. [Abstract]2025 Nov 25;99(11):e0098525. PMID: 41171159 -
Viruses
Asparagine Availability Is a Critical Limiting Factor for Infectious Spleen and Kidney Necrosis Virus Replication. [Abstract]2024 Sep 29;16(10):1540. PMID: 39459874 -
Am J Transl Res
H2S promotes proliferation of endometrial stromal cells via activating the NF-κB pathway in endometriosis. [Abstract]2018 Dec 15;10(12):4247-4257. PMID: 30662667 -
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Biomed Pharmacother
Aminooxyacetic acid hemihydrochloride leads to decreased intracellular ATP levels and altered cell cycle of prostate cancer cells by suppressing energy metabolism. [Abstract]2023 Nov:167:115605. PMID: 37801901 -
Comput Biol Med
System analysis based on glutamine catabolic-related enzymes identifies GPT2 as a novel immunotherapy target for lung adenocarcinoma. [Abstract]2023 Oct:165:107415. PMID: 37657356
Pureté et documentation
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Fiche technique (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Wang C, et al. Malate-aspartate shuttle inhibitor aminooxyacetic acid leads to decreased intracellular ATP levels and altered cell cycle of C6 glioma cells by inhibiting glycolysis. Cancer Lett. 2016 Aug 1;378(1):1-7. [Content Brief]
[2]. Pagliusi SR, et al. Aminooxyacetic acid induced accumulation of GABA in the rat brain. Interaction with GABA receptors and distribution in compartments. Naunyn Schmiedebergs Arch Pharmacol. 1983 Apr;322(3):210-5. [Content Brief]
[3]. Korangath P, et al. Targeting Glutamine Metabolism in Breast Cancer with Aminooxyacetate. Clin Cancer Res. 2015 Jul 15;21(14):3263-73. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Aminoxyacetic acid Related Classifications
HY-107994A Related Classifications
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