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Aminoxyacetic acid

(Synonyms: Carboxymethoxylamine; Aminooxyacetate)
24 Cited Publications
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Based on 24 publication(s) in Google Scholar

Aminooxyacetic acid (Carboxymethoxylamine) is a malate-aspartate shuttle (MAS) inhibitor. Aminooxyacetic acid also inhibits the GABA degradating enzyme GABA-T.

For research use only. We do not sell to patients.

  • Purity: 95.0%
  • CAS No.: 645-88-5
  • Formula: C2H5NO3
  • Molecular Weight:91.07
  • Storage:
    Powder   -20°C, 3 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • Aminoxyacetic acid Chemical Structure
    Aminoxyacetic acid Chemical Structure
  • Experimental Validation Results for Aminoxyacetic acid
  • Experimental Validation Results for Aminoxyacetic acid
  • Experimental Validation Results for Aminoxyacetic acid
  • Experimental Validation Results for Aminoxyacetic acid
  • Experimental Validation Results for Aminoxyacetic acid
CAS No.: 645-88-5
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  • Aminoxyacetic acid Chemical Structure
    Aminoxyacetic acid Chemical Structure
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    Aminoxyacetic acid purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2023 Feb 15;8(1):65. [Abstract]

    Customer Validation
     Aminooxyacetic acid hemihydrochloride (AOA) (20 μM; 48 h) decreased the migration and invasion of HCC cells expressing p5372P variant.

  • 1/16

    Aminoxyacetic acid purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2023 Feb 15;8(1):65. [Abstract]

    Customer Validation
     A Parental or PSAT1 knockout PLC/PRF/5 cells were tail intravenously injected into BALB/c nude mice and the mice were treated with vehicle or Aminooxyacetic acid hemihydrochloride (AOA) (10 mg/kg; i.p.; once daily for 14 d). Aminooxyacetic acid hemihydrochloride (AOA) treatment significantly inhibited the lung metastasis of cancer cells expressing the p5372P variant in vivo.

  • 1/16

    Aminoxyacetic acid purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2023 Feb 15;8(1):65. [Abstract]

    Customer Validation
     The interaction between PSAT1 and p53 was diminished by Aminooxyacetic acid hemihydrochloride (AOA) (10-20 μM) treatment while the protein level of PSAT1 was not significantly changed.

  • 1/16

    Aminoxyacetic acid purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2023 Feb 15;8(1):65. [Abstract]

    Customer Validation
     Cell viability of Hep3B cells transfected with vector, p53-72P, and p53-72R plasmids was assessed. Cells were treated with regorafenib alone or Aminooxyacetic acid hemihydrochloride (AOA) (10 μM) plus regorafenib at indicated concentrations. Aminooxyacetic acid hemihydrochloride (AOA) sensitized tumor cells containing vector and p53-72P to regorafenib, while exhibiting no obvious synergistic function with regorafenib in cells containing p53-72R.

  • 1/16

    Aminoxyacetic acid purchased from MedChemExpress. Usage Cited in: Nat Metab. 2022 Feb;4(2):239-253. [Abstract]

    Customer Validation
     Aminooxyacetic acid hemihydrochloride (GOT1) (1 mM; 2 d). Cell proliferation of H460 cells was quantified after treatment with inhibitors against the indicated enzymes.

  • Aminoxyacetic acid