2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. PM534

PM534, tubulin targeting agent, inhibits tubulin assembly with IC50 values of 0.8-3.2 nM. PM534 binds to the colchicine site of tubulin, which has high antitumor activity.

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PM534

PM534 Chemische Struktur

CAS. Nr. : 2446376-25-4

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PM534 Related Antibodies

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Beschreibung

PM534, tubulin targeting agent, inhibits tubulin assembly with IC50 values of 0.8-3.2 nM. PM534 binds to the colchicine site of tubulin, which has high antitumor activity[1].

Cellular Effect
Cell Line Type Value Description References
A2780 IC50
1.4 nM
Compound: PM534
Antiproliferative activity against human A2780 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human A2780 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
[PMID: 38294341]
A549 IC50
1.5 nM
Compound: PM534
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
[PMID: 38294341]
HeLa IC50
1.3 nM
Compound: PM534
Antiproliferative activity against human HeLa cells expressing tubulin betaIII assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells expressing tubulin betaIII assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
[PMID: 38294341]
HeLa IC50
1.6 nM
Compound: PM534
Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
[PMID: 38294341]
Klinische Studie
Molekulargewicht

421.51

Formel

C20H27N3O5S
CAS. Nr.
SMILES

O=C([C@]1(N=C(SC1)/C(C)=N/O)C)N[C@@H](C2=CC(OCC3CC3)=CC(O2)=O)CCC
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
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PM534 Related Classifications

  • Molaritätsrechner

  • Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)

Diese Gleichung wird häufig abgekürzt als: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PM5342446376-25-4PM 534PM-534Microtubule/TubulinColchicineantitumorA549HelaA2780Inhibitorinhibitorinhibit

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