RANTES: a versatile and controversial chemokine

  • Trends Immunol. 2001 Feb;22(2):83-7. doi: 10.1016/s1471-4906(00)01812-3.
V Appay  1 ,  S L Rowland-Jones
Affiliations
  • 1. Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, OX3 9DS, Oxford, UK. [email protected]
PMID: 11286708 DOI: 10.1016/s1471-4906(00)01812-3
Abstract

The activity of the chemokine RANTES is not restricted merely to chemotaxis. It is a powerful leukocyte activator, a feature potentially relevant in a range of inflammatory disorders. RANTES has attracted attention because it can potently suppress and, in some circumstances, enhance HIV replication. These characteristics are critically dependent on its ability to self-aggregate and bind to glycosaminoglycans.

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