Guadial A and psiguadials C and D, three unusual meroterpenoids from Psidium guajava
- Org Lett. 2012 Oct 19;14(20):5262-5. doi: 10.1021/ol302423b.
Affiliations
- 1. Institute of Traditional Chinese Medicine & Natural Products, Jinan University, Guangzhou 510632, PR China.
PMID: 23020279
DOI: 10.1021/ol302423b
Abstract
The first monoterpene-based meroterpenoid (1) and two novel sesquiterpene-based ones (2 and 3) with unprecedented skeletons were isolated from the leaves of Psidium guajava. Their structures with absolute configuration were elucidated by extensive spectroscopic studies. A plausible biosynthetic pathway for all meroterpenoids from the title plant is also proposed. Compounds 2 and 3 showed significant cytotoxicity toward HepG2 and HepG2/ADM cells.
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