Chemical Constituents from the Fruiting Bodies of Hexagonia apiaria and Their Anti-inflammatory Activity

  • J Nat Prod. 2015 Nov 25;78(11):2552-8. doi: 10.1021/acs.jnatprod.5b00449.
Tran Dinh Thang  1 ,  Ping-Chung Kuo  2 ,  Nguyen Thi Bich Ngoc  1 ,  Tsong-Long Hwang  3  4 ,  Mei-Lin Yang  2 ,  Shih-Huang Ta  5 ,  E-Jian Lee  5 ,  Dai-Huang Kuo  6 ,  Nguyen Huy Hung  1 ,  Nguyen Ngoc Tuan  1 ,  Tian-Shung Wu  6  7
Affiliations
  • 1. Department of Chemistry, Vinh University , Vinh City 42000, Vietnam.
  • 2. Department of Biotechnology, National Formosa University , Yunlin 63201, Taiwan, ROC.
  • 3. Graduate Institute of Natural Products, Chang Gung University , Taoyuan 33302, Taiwan, ROC.
  • 4. Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University , Taoyuan 33302, Taiwan, ROC.
  • 5. Neurosurgical Service, Department of Surgery, National Cheng Kung Medical Center and Medical School , Tainan, Taiwan, ROC.
  • 6. Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University , Pingtung 90741, Taiwan, ROC.
  • 7. School of Pharmacy, National Cheng Kung University , Tainan 70101, Taiwan, ROC.
PMID: 26575215 DOI: 10.1021/acs.jnatprod.5b00449
Abstract

A chemical investigation of the fruiting bodies of Hexagonia apiaria resulted in the identification of nine compounds including five new triterpenoids, hexagonins A-E (1-5), along with four known compounds. The purified constituents were examined for their anti-inflammatory activity. Among the tested compounds, hexatenuin A displayed the most significant inhibition of superoxide anion generation and Elastase release. These triterpenoids may have potentials as anti-inflammatory agents.